{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:27:04Z","timestamp":1788838024079,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"New National Excellence Program of the Ministry of Human Capacities","award":["UNKP-17-4"],"award-info":[{"award-number":["UNKP-17-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Enantioseparation of the antidiarrheal drug, racecadotril, was investigated by liquid chromatography using polysaccharide\u2010type chiral stationary phases in polar organic mode. The enantiodiscrimininating properties of 4 different chiral columns (Chiralpak AD, Chiralcel OD, Chiralpak AS, Chiralcel OJ) with 5 different solvents (methanol, ethanol, 1\u2010propanol, 2\u2010propanol, and acetonitrile) at 5 different temperatures (5\u201340\u00a0\u00b0C) were investigated. Apart from Chiralpak AS column the other 3 columns showed significant enantioseparation capabilities. Among the tested mobile phases, alcohol type solvents were superior over acetonitrile, and significant differences in enantioselective performance of the selector were observed depending on the type of alcohol employed. Van't Hoff analysis was used for calculation of thermodynamic parameters which revealed that enantioseparation is mainly enthalpy controlled; however, enthropic control was also observed. Enantiopure standard was used to determine the enantiomer elution order, revealing chiral selector\u2014and mobile\u2010phase dependent reversal of enantiomer elution order. Using the optimized method (Chiralcel OJ stationary phase, thermostated at 10\u00a0\u00b0C, 100% methanol, flow rate: 0.6\u00a0mL\/min) baseline separation of racecadotril enantiomers (resolutio<jats:italic>n<\/jats:italic>\u00a0=\u00a03.00\u00a0\u00b1\u00a00.02) was achieved, with the R\u2010enantiomer eluting first. The method was validated according to the ICH guidelines, and its application was tested on capsule and granules containing the racemic mixture of the drug.<\/jats:p>","DOI":"10.1002\/chir.22772","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T15:16:35Z","timestamp":1507734995000},"page":"95-105","source":"Crossref","is-referenced-by-count":21,"title":["Enantioseparation of racecadotril using polysaccharide\u2010type chiral stationary phases in polar organic mode"],"prefix":"10.1002","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8740-0212","authenticated-orcid":false,"given":"Zolt\u00e1n\u2010Istv\u00e1n","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy University of Medicine and Pharmacy T\u00eergu Mure\u015f T\u00eergu Mure\u015f 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