{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:32:01Z","timestamp":1789727521015,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The stereoselective analysis and separation of racemic drugs play an important role in pharmaceutical industry to eliminate the unwanted isomer and find the right therapeutic control for the patient. Present study suggests a maltodextrin\u2010modified capillary electrophoresis method for a single\u2010run chiral separation of two closely similar opiate pain relief drugs: tramadol (TRA) and methadone (MET). The best separation method possible for the both enantiomers was achieved on an uncoated fused\u2010silica capillary at 25\u00b0C using 100 mM phosphate buffer (pH\u00a08.0) containing 20% (w\u00a0v<jats:sup>\u22121<\/jats:sup>) maltodextrin with dextrose equivalent of 4\u20137 and an applied voltage of 16\u00a0kV. Under optimal conditions, the baseline resolution of TRA and MET enantiomers was obtained in less than 12\u00a0minutes. The relative standard deviations (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) of 20\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup> TRA and MET were 2.28% and 3.77%, respectively. The detection limits were found to be 2\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup> for TRA and 1.5\u00a0\u03bcg\u00a0mL<jats:sup>\u22121<\/jats:sup> for MET. This method was successfully applied to the measurement of drugs concentration in their tablets, urine, and plasma samples.<\/jats:p>","DOI":"10.1002\/chir.23008","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T14:58:58Z","timestamp":1534949938000},"page":"1161-1168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Simultaneous chiral separation of tramadol and methadone in tablets, human urine, and plasma by capillary electrophoresis using maltodextrin as the chiral selector"],"prefix":"10.1002","volume":"30","author":[{"given":"Elahe","family":"Naghdi","sequence":"first","affiliation":[{"name":"Faculty of Chemistry Shahid Beheshti University  G.C., Tehran I.R. Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2032-5040","authenticated-orcid":false,"given":"Ali Reza","family":"Fakhari","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Shahid Beheshti University  G.C., Tehran I.R. Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"85","article-title":"Chiral drugs: an overview","volume":"2","author":"Nguyen LA","year":"2006","journal-title":"J Biomed Sci"},{"issue":"11","key":"e_1_2_5_3_1","first-page":"1742","article-title":"Clinical investigation on the development of dependence during oral therapy with tramadol","volume":"35","author":"Richter W","year":"1985","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01597.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-4166(01)00293-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199606000-00001"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.11.025"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.10.053"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.09.009"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-636X(1999)11:4<319::AID-CHIR10>3.0.CO;2-Y"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.20025"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(97)00605-1"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(96)01748-7"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200305418"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201100021"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200406052"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac981178v"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2008.11.043"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10337-010-1891-4"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032710903060768"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201100426"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201000242"},{"key":"e_1_2_5_23_1","first-page":"255","article-title":"Chiral separations using the macrocyclic antibiotics in capillary electrophoresis","author":"Ward TJ","year":"2004","journal-title":"Chiral Separ Metho Protocol"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02490991"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00093a037"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2003.11.097"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201300222"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.220"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00092a028"},{"key":"e_1_2_5_30_1","first-page":"69","article-title":"Carbohydrates as chiral selectors for capillary electrophoresis of racemic drugs","volume":"2","author":"D'Hulst A","year":"1997","journal-title":"Enantiomer"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.530060403"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150190706"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.1150191614"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00501-X"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(96)00273-7"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(20017)22:11<2129::AID-ELPS2129>3.0.CO;2-J"}],"container-title":["Chirality"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchir.23008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chir.23008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:04:36Z","timestamp":1694995476000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/chir.23008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,20]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1002\/chir.23008"],"URL":"https:\/\/doi.org\/10.1002\/chir.23008","archive":["Portico"],"relation":{},"ISSN":["0899-0042","1520-636X"],"issn-type":[{"value":"0899-0042","type":"print"},{"value":"1520-636X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,20]]},"assertion":[{"value":"2018-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}