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One element small molecule alcohol\u2010salt aqueous two\u2010phase system (ATPS) cannot effectively adjust the polarity of the system, but binary small molecule alcohol\u2010salt ATPS can adjust the polarity and improve the extraction efficiency of antibiotics. In this work, a binary ATPS based on ethanol +2\u2010propanol\u00a0+\u00a0(NH<jats:sub>4<\/jats:sub>)<jats:sub>2<\/jats:sub>SO<jats:sub>4<\/jats:sub> system was formed and applied to the separation and purification of TC in real water samples. The influence factors on partition behaviors of TC were discussed, including the types and the concentration of phase salts, the volume ratio of alcohol, the pH value, extraction temperature, and the standing time. The response surface methodology was used to determine the best experimental conditions for multi\u2010factor experiments. Under this optimal condition, the extraction efficiency of TC reached 95.7%. This new method is considered to have significant application in the divorce of antibiotics.<\/jats:p>","DOI":"10.1002\/chir.23080","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T10:19:38Z","timestamp":1562149178000},"page":"658-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Separation and determination of tetracycline hydrochloride in real water samples using binary small molecule alcohol\u2010salt aqueous two\u2010phase system coupled with high\u2010performance liquid chromatography"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7550-1868","authenticated-orcid":false,"given":"Dong\u2010gang","family":"Guo","sequence":"first","affiliation":[{"name":"School of the Environmental and Safety Engineering, School of Chemistry and Chemical Engineering Jiangsu University  Zhenjiang China"},{"name":"Key Laboratory of Preparation and 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