{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T02:05:45Z","timestamp":1786673145071,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, a series of fluorine\u2010containing chiral hydrazide\u2010hydrazone derivatives<jats:bold>[III\u2010XII]<\/jats:bold>from \u029f\u2010cysteine ethyl ester hydrochloride was synthesized as new antioxidant and anticholinesterase agents. The antioxidant activity of these derivatives was evaluated by ABTS<jats:sup>+\u00b7<\/jats:sup>and DPPH<jats:sup>\u00b7<\/jats:sup>scavenging and CUPRAC assays and the anticholinesterase activity by the Ellman method spectrophotometrically. The results of the antioxidant assay showed that compounds<jats:bold>V<\/jats:bold>,<jats:bold>IX<\/jats:bold>, and<jats:bold>X<\/jats:bold>exhibited higher activity than BHT and<jats:italic>\u03b1<\/jats:italic>\u2010tocopherol used as positive standards. Among the synthesized derivatives, compound<jats:bold>IX<\/jats:bold>(IC<jats:sub>50<\/jats:sub>: 2.3\u00a0\u00b1\u00a01.6\u00a0\u03bcM) exhibited higher acetylcholinesterase inhibitory activity than galantamine (IC<jats:sub>50<\/jats:sub>: 4.5\u00a0\u00b1\u00a00.8\u00a0\u03bcM).<\/jats:p><jats:p>Compounds<jats:bold>XI<\/jats:bold>(IC<jats:sub>50<\/jats:sub>: 9.6\u00a0\u00b1\u00a01.0\u00a0\u03bcM),<jats:bold>IX<\/jats:bold>(IC<jats:sub>50<\/jats:sub>: 12.5\u00a0\u00b1\u00a01.6\u00a0\u03bcM),<jats:bold>III<\/jats:bold>(IC<jats:sub>50<\/jats:sub>: 16.0\u00a0\u00b1\u00a01.6\u00a0\u03bcM),<jats:bold>X<\/jats:bold>(IC<jats:sub>50<\/jats:sub>: 17.2\u00a0\u00b1\u00a01.8\u00a0\u03bcM),<jats:bold>VI<\/jats:bold>(IC<jats:sub>50<\/jats:sub>: 20.2\u00a0\u00b1\u00a00.8\u00a0\u03bcM),<jats:bold>XII<\/jats:bold>(IC<jats:sub>50<\/jats:sub>: 21.5\u00a0\u00b1\u00a01.0\u00a0\u03bcM), and<jats:bold>VII<\/jats:bold>(IC<jats:sub>50<\/jats:sub>: 24.6\u00a0\u00b1\u00a00.6\u00a0\u03bcM) displayed better butyrylcholinesterase inhibitory activity than galantamine (IC<jats:sub>50<\/jats:sub>: 46.03\u00a0\u00b1\u00a00.14\u00a0\u03bcM). ADME\u2010Tox analysis was used to probe the drug\u2010like properties of the compounds. Molecular docking studies were also applied to understand the interactions between compounds and targets. The docking calculations were supported by the experimental data. In particular, compound<jats:bold>IX<\/jats:bold>, having better activity than galantamine against acetylcholinesterase and butyrylcholinesterase enzymes, was visualized using molecular docking.<\/jats:p>","DOI":"10.1002\/chir.23102","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T05:30:13Z","timestamp":1561095013000},"page":"603-615","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Novel fluorine\u2010containing chiral hydrazide\u2010hydrazones: Design, synthesis, structural elucidation, antioxidant and anticholinesterase activity, and<i>in silico<\/i>studies"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2339-5837","authenticated-orcid":false,"given":"Yusuf","family":"S\u0131cak","sequence":"first","affiliation":[{"name":"K\u00f6yce\u011fiz Vocational School Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University Mu\u011fla 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