{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:53:39Z","timestamp":1786481619281,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011259","name":"FP7 International Cooperation","doi-asserted-by":"publisher","award":["21320102007"],"award-info":[{"award-number":["21320102007"]}],"id":[{"id":"10.13039\/100011259","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["International Cooperation Grant No. 21320102007"],"award-info":[{"award-number":["International Cooperation Grant No. 21320102007"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Key Programme Grant No. 21427815"],"award-info":[{"award-number":["Key Programme Grant No. 21427815"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Perfluorooctane sulfonate (PFOS) is one of the most frequently detected perfluoroalkyl substances in environmental and human samples. Previous studies have shown that nonracemic PFOS in biological samples can be used as a marker of PFOS exposure sources. In recent years, supercritical fluid chromatography (SFC) has emerged as a powerful method to separate chiral compounds. In this study, a method of perfluoro\u20101\u2010methylheptane sulfonate (1\u00a0<jats:italic>m<\/jats:italic>\u2010PFOS) enantioseparation by SFC was established. The optimal separation was obtained using a Chiralpak QN\u2010AX column with CO<jats:sub>2<\/jats:sub>\/2\u2010propanol (70\/30, v\/v) as the mobile phase with a flow rate of 1\u00a0mL\/min, column temperature was 32\u00b0C, and BPR pressure was 1800\u00a0psi. The resolution (<jats:italic>Rs<\/jats:italic>) and retention time were 0.88 and 130\u00a0minutes, respectively. This method is more economic and greener than HPLC. Modifier pH and column temperature were determined to be significant factors of SFC chiral separation. Modifier pH is negatively correlated with the retention factors and <jats:italic>Rs<\/jats:italic>. Adsorption thermodynamics were used to explain the influence of temperature change, and it was concluded that the transfer of two enantiomers from the mobile phase to the stationary phase is enthalpy\u2010driven. Enantioseparation of 1\u00a0<jats:italic>m<\/jats:italic>\u2010PFOS by SFC follows the same rules of ion exchange as those for the chiral separation by HPLC.<\/jats:p>","DOI":"10.1002\/chir.23120","type":"journal-article","created":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T11:41:47Z","timestamp":1565696507000},"page":"870-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Enantioseparation of chiral perfluorooctane sulfonate (PFOS) by supercritical fluid chromatography (SFC): Effects of the chromatographic conditions and separation mechanism"],"prefix":"10.1002","volume":"31","author":[{"given":"Lu","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute of Environmental Health, College of Environmental and Resource Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Environmental Health, College of Environmental and Resource Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjie","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Environmental Health, College of Environmental and Resource Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1173-892X","authenticated-orcid":false,"given":"Weiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Environmental Health, College of Environmental and Resource Sciences Zhejiang University  Hangzhou 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