{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:25:57Z","timestamp":1789403157854,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T00:00:00Z","timestamp":1572912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bath salts, fumigations, cleaners and air fresheners, behind these terms substances are hidden, which count as \u201cLegal Highs\u201d. These fancy names are used to pretend Legal Highs as harmless compounds, to circumvent legal regulations for marketing as well as to increase the sales. Besides classic illicit drugs of synthetic origin such as amphetamines, cocaine and MDMA, the trade of these compounds, also known as new psychoactive substances (NPS), is not uncommon today. In many countries, NPS are still not subject to drug control. Among them, there are stimulants such as new amphetamine derivatives or cathinones, which possess a chiral centre. Little is known about the fact that the two possible enantiomers may differ in their pharmacological effect. The aim of this study was to test a novel HPLC column for the enantioseparation of a set of 112 NPS coming from different chemical groups and collected by internet purchases during the years 2010\u20132018. The CSP, namely Lux\u00ae 5\u00a0\u03bcm i\u2010Amylose\u20101, LC Column 250 x 4.6\u00a0mm, was run in normal phase mode under isocratic conditions, UV detection was performed at 245\u00a0nm and 230\u00a0nm, injection volume was 10\u00a0\u03bcl and flow rate was 1\u00a0ml\/min. With a mobile phase consisting of n\u2010hexane\/isopropanol\/diethylamine (90:10:0.1), herein, 79 NPS were resolved into their enantiomers successfully, for 37 of them baseline resolution was achieved. After increase of lipophily of the mobile phase to 99:1:0.1, another 27 compounds were baseline separated. It was found that all separated NPS are traded as racemic compounds.<\/jats:p>","DOI":"10.1002\/chir.23135","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T16:49:16Z","timestamp":1572972556000},"page":"42-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Successful use of a novel lux\u00ae i\u2010Amylose\u20101 chiral column for enantioseparation of \u201clegal highs\u201d by HPLC"],"prefix":"10.1002","volume":"32","author":[{"given":"Kian","family":"Kadkhodaei","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Institute of Pharmaceutical Sciences  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Kadisch","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Institute of Pharmaceutical Sciences  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0055-660X","authenticated-orcid":false,"given":"Martin G.","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Institute of Pharmaceutical Sciences  Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.09.030"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.155"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci8070123"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00212"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201701239"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scijus.2016.08.007"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.11.001"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.22414"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.09.079"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2016.600105"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1520\/JFS15556J"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.22981"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0379-0738(03)00096-3"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2017.02.010"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11419-018-0427-8"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bky037"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201800006"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2016.04.046"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2017.08.031"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201100570"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.22048"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201400164"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2016.10.011"},{"key":"e_1_2_5_25_1","unstructured":"Phenomenex.https:\/\/www.phenomenex.com\/Products\/HPLCDetail\/lux."},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-015-9247-4"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-013-7386-z"},{"key":"e_1_2_5_28_1","first-page":"301","article-title":"CHAPTER 11 Optical Detection of NPS Internet Products via HPLC\u2010DAD Systems: A Selective Review. 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