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To date, methods were developed only for the assay of <jats:sc>l<\/jats:sc>\u2010tryptophan, the role of <jats:sc>d<\/jats:sc>\u2010tryptophan being not yet established. Therefore, four stochastic sensors based on different graphene materials modified with \u03b2\u2010cyclodextrins, 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl, and protoporphyrin IX were designed and used for enantioanalysis of tryptophan in whole blood samples. High sensitivities, and reliabilities were recorded when the stochastic sensors were used for the enantioanalysis of tryptophan in whole blood samples. 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