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The factors that affected the enantioseparation were tested and optimized to develop a suitable chiral separation method whose LC conditions are compatible with MS detection. In polar\u2010organic elution mode with the Lux Cellulose\u20101 column, methanol and acetonitrile were tested as the main components of the mobile phase. In addition, the effects of adding isopropanol as organic modifier, acidic additives (formic acid), and basic additives (diethylamine) were evaluated. In reversed\u2010phase elution mode with the Chiralpak CBH column, the effect of type and concentration of organic modifier (isopropanol, acetonitrile, and methanol), the mobile phase pH (6.4 and 5.0), and buffer concentration (1mM\u201020mM ammonium acetate) were evaluated. The best enantioseparation was achieved with the Chiralpak CBH column with a mobile phase composed of 5mM ammonium acetate aqueous (pH = 6.4)\/methanol (95\/5, v\/v) at a flow rate of 0.1 mL\/min and a temperature of 30\u00b0C. Under these conditions, six of eight chiral drugs were baseline separated.<\/jats:p>","DOI":"10.1002\/chir.23198","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T16:55:32Z","timestamp":1582217732000},"page":"876-884","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of polysaccharide\u2010based and protein\u2010based chiral liquid chromatography columns for enantioseparation of drugs"],"prefix":"10.1002","volume":"32","author":[{"given":"Yandi","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry and Organic Chemistry Universitat Rovira i Virgili Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Borrull","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry and Organic Chemistry Universitat Rovira i Virgili Tarragona 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