{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:21:29Z","timestamp":1779164489872,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003500","name":"Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","award":["DOR\u20102018"],"award-info":[{"award-number":["DOR\u20102018"]}],"id":[{"id":"10.13039\/501100003500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>S<\/jats:italic>(+)\u2010ibuprofen (<jats:italic>S<\/jats:italic>\u2010IBU) and <jats:italic>R<\/jats:italic>(\u2212)\u2010ibuprofen (<jats:italic>R<\/jats:italic>\u2010IBU) concentrations were measured in 16 neonates with patent ductus arteriosus during a cycle of therapy (three intravenous doses of 10\u20135\u20135 mg\u2009kg<jats:sup>\u22121<\/jats:sup> at 24\u2010h intervals), at the end of the first infusion and 6, 24, 48, and 72\u2009h later. Data were analyzed with a PK model that included enantiomer elimination rate constants and the <jats:italic>R<\/jats:italic>\u2010 to <jats:italic>S<\/jats:italic>\u2010IBU conversion rate constant. The <jats:italic>T<\/jats:italic>\u00bd of <jats:italic>S<\/jats:italic>\u2010IBU in the newborn was much longer than in adults (41.8 vs. \u22482 h), whereas the <jats:italic>T<\/jats:italic>\u00bd of <jats:italic>R<\/jats:italic>\u2010IBU appeared to be the same (2.3 h). The mean fraction of <jats:italic>R<\/jats:italic>\u2010 to <jats:italic>S<\/jats:italic>\u2010IBU conversion was much the same as in adults (0.41 vs. \u22480.60). <jats:italic>S<\/jats:italic>\u2010IBU concentrations measured 6 h after the first dose were higher than at the end of the infusion in 10 out of 16 cases, and in five cases, they remained higher even after 24\u2009h. This behavior is unprecedented and may be attributable to a rapid <jats:italic>R<\/jats:italic>\u2010to\u2010<jats:italic>S<\/jats:italic> conversion overlapping with a slow <jats:italic>S<\/jats:italic>\u2010IBU elimination rate. In 13 of the 16 neonates, <jats:italic>S<\/jats:italic>\u2010IBU concentrations at 48 and\/or 72\u2009h were lower than expected, probably due to the rapid postnatal maturation of the newborn's liver metabolism.<\/jats:p>","DOI":"10.1002\/chir.23308","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T01:21:55Z","timestamp":1616980915000},"page":"281-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ibuprofen enantiomers in premature neonates with patent ductus arteriosus: Preliminary data on an unexpected pharmacokinetic profile of <i>S<\/i>(+)\u2010ibuprofen"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9699-3673","authenticated-orcid":false,"given":"Roberto","family":"Padrini","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Unit, Department of Medicine University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Ancora","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Women's and Children's Health University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Nardo","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Women's and Children's Health University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"De Rosa","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Unit, Department of Medicine University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Salvadori","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Women's and Children's Health University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bonadies","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Women's and Children's Health University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Chiara","family":"Frigo","sequence":"additional","affiliation":[{"name":"Biostatistics, Epidemiology and Public Health Unit, Department of Cardiac\u2010Thoracic\u2010Vascular Sciences and Public Health University of Padova  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Lago","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Department of Women's and Children's Health University of Padova  Padova Italy"},{"name":"Neonatal Intensive Care Unit, Women's and Children's Department C\u00e0 Foncello Hospital  Treviso 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