{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:13Z","timestamp":1786977373321,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T00:00:00Z","timestamp":1620604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Asymmetric bioreduction of ketones is a fundamental process in the production of organic molecules. Compounds containing tetralone rings are found in the structure of many biologically active and pharmaceutical molecules. Biocatalytic reduction of ketones is one of the most promising and significant routes to prepare optically active alcohols. In this study, the reductive capacity of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lactobacillus paracasei<\/jats:italic>\n                    <\/jats:styled-content>\n                    BD101 was investigated as whole\u2010cell biocatalyst in the enantioselective reduction of 1\u2010tetralone (\n                    <jats:bold>1<\/jats:bold>\n                    ). In biocatalytic reduction reactions, the conversion of the substrate and the enantiomeric excess (ee) of the product are significantly affected by optimization parameters such as temperature, agitation rate, pH, and incubation time. Effects of these parameters on ee and conversion were investigated comprehensively. (\n                    <jats:italic>R<\/jats:italic>\n                    )\u20101\u2010tetralol (\n                    <jats:bold>\n                      (\n                      <jats:italic>R<\/jats:italic>\n                      )\u20102\n                    <\/jats:bold>\n                    ), which can be used to treat disorder such as obsessive compulsive, post\u2010traumatic stress, premenstrual dysphoric, and social anxiety, was manufactured in enantiopure form, high yield and gram\u2010scale, using whole\u2010cell biocatalysts of\n                    <jats:italic>L.\u00a0paracasei<\/jats:italic>\n                    BD101. The 7.04\u2009g of\n                    <jats:bold>\n                      (\n                      <jats:italic>R<\/jats:italic>\n                      )\u20102\n                    <\/jats:bold>\n                    was obtained in optically pure form with 95% yield. Also, to our knowledge, this is the first report on production of\n                    <jats:bold>\n                      (\n                      <jats:italic>R<\/jats:italic>\n                      )\u20102\n                    <\/jats:bold>\n                    using whole\u2010cell biocatalyst in excellent yield, conversion, enantiopure form and gram scale. This is a clean, eco\u2010friendly and cheap method for the synthesis of\n                    <jats:bold>\n                      (\n                      <jats:italic>R<\/jats:italic>\n                      )\u20102\n                    <\/jats:bold>\n                    compared with chemical catalyst.\n                  <\/jats:p>","DOI":"10.1002\/chir.23318","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T10:07:06Z","timestamp":1620641226000},"page":"447-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Biocatalytic asymmetric synthesis of (\n                    <i>R<\/i>\n                    )\u20101\u2010tetralol using\n                    <scp>\n                      <i>Lactobacillus paracasei<\/i>\n                    <\/scp>\n                    BD101"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4656-8254","authenticated-orcid":false,"given":"Erbay","family":"Kalay","sequence":"first","affiliation":[{"name":"Kars Vocational School Kafkas University  Kars Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-1705","authenticated-orcid":false,"given":"Engin","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Department of Nutrition and Dietetics Bayburt University  Bayburt 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