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The bulky <jats:italic>t<\/jats:italic>\u2010butyl ketone extractors, (<jats:italic>R<\/jats:italic>)\u2010<jats:bold>4<\/jats:bold> and (<jats:italic>R<\/jats:italic>)\u2010<jats:bold>5<\/jats:bold>, showed the stereoselectivities ranging 5.4\u20139.4 of <jats:sc>l\/d<\/jats:sc> ratio much better than those of the aldehyde extractor, (<jats:italic>R<\/jats:italic>)\u2010<jats:bold>3<\/jats:bold>, ranging 2.4\u20135.2. The imine formation rates and yields of the <jats:italic>t<\/jats:italic>\u2010butyl ketones were not significantly affected by their bulkiness and even in the absence of resonance\u2010assisted hydrogen bond. This work confirms that a bulky <jats:italic>t<\/jats:italic>\u2010butyl ketone can be a good choice in the development of an extractor not only with axial chirality but also with nonaxial chirality for the enantioselective extraction of unprotected amino acids.<\/jats:p>","DOI":"10.1002\/chir.23449","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T12:38:31Z","timestamp":1649853511000},"page":"999-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Remarkable enantioselectivity enhancement of the extractors with nonaxial chirality in liquid\u2013liquid extraction of underivatized amino acids by introducing <i>t<\/i>\u2010butyl group"],"prefix":"10.1002","volume":"34","author":[{"given":"Yingji","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Chemistry and Nano Science Ewha Womans University  Seoul 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