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The phenolic sulfonamide produced from 2,4\u2010dihydroxybenzenesulfonic acid (HBS) and (+)\u2010Cat ((+)\u2010Cat\u2010HBS) was initially synthesized by triphenylphosphene activation and subsequently involved in condensation polymerization with resorcinol in the presence of formaldehyde under acidic conditions. Alkaline sulfonamide bond\u2010breaking was subsequently employed to separate the (+)\u2010Cat template from the polymer, and the resulting imprinted resin ((+)\u2010CIP) displayed high selectivity for the (+)\u2010Cat, with a capacity of 225\u2009\u00b1\u20092\u00a0mg\/g. Studies of selectivity also showed that the (+)\u2010Cat enantiomer was preferred over its counterpart because of the development of configurationally matching receptors. In addition, the produced resin was used for the enantioresolution of (\u00b1)\u2010Cat racemate by column method, yielding a loading supernatant solution with an enantiomeric excess of (+)\u2010Cat 50% and a recovery eluant solution with an excess of (\u2212)\u2010Cat 85%.<\/jats:p>","DOI":"10.1002\/chir.23594","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T11:43:40Z","timestamp":1685015020000},"page":"766-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design of molecularly imprinted resin material with sulfonic acid functionalization for enantioseparation of (\u00b1)\u2010cathine"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8019-1563","authenticated-orcid":false,"given":"Aliyah S.","family":"Alhawiti","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science University of Tabuk  Tabuk Saudi 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