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The mobile phase composed of n\u2010Heptane, isopropyl alcohol, dichloromethane, ethanol, and diethylamine in the ratio of 70:10:15:5:0.1 (V\/V\/V\/VV) with a gradient flow rate was applied. The injection volume was 10\u2009\u03bcl, and detection was carried out using a photodiode array detector at 282\u2009nM. The column compartment was set at 35\u00b0C. The resolution between the enantiomer and isomers was found to be more than 2.0. The method was linear over the concentration range of limit of quantitation to 250% for isomers and enantiomers. The method was found to be robust with column temperature. The proposed chiral method is applicable for the determination of isomers and enantiomer of Valibenazine and was successfully used in the quality control of bulk drug manufacturing and pharmaceuticals.<\/jats:p>","DOI":"10.1002\/chir.23600","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T09:49:45Z","timestamp":1687600185000},"page":"889-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Valbenazine isomers and enantiomer determination by chiral normal phase liquid chromatography"],"prefix":"10.1002","volume":"35","author":[{"given":"Balasaheb R.","family":"Deshmukh","sequence":"first","affiliation":[{"name":"Department of Chemistry, GITAM School of Science GITAM Deemed to be University Visakhapatnam Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parameswari","family":"Akshinthala","sequence":"additional","affiliation":[{"name":"Department of Science and Humanities MLR Institute of Technology Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5737-8528","authenticated-orcid":false,"given":"Naresh Kumar","family":"Katari","sequence":"additional","affiliation":[{"name":"Department of Chemistry, GITAM School of Science GITAM Deemed to be University Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1199-2458","authenticated-orcid":false,"given":"Leela Prasad","family":"Kowtharapu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, GITAM School of Science GITAM Deemed to be University Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish K.","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Department of Chemistry, GITAM School of Science GITAM Deemed to be University Visakhapatnam Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenivas Rao","family":"Battula","sequence":"additional","affiliation":[{"name":"Department of Chemistry, GITAM School of Science GITAM Deemed to be University Visakhapatnam Andhra Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rambabu","family":"Gundla","sequence":"additional","affiliation":[{"name":"Department of Chemistry, GITAM School of Science GITAM Deemed to be University Hyderabad Telangana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.530060206"},{"issue":"2","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.59566\/IJBS.2006.2085","article-title":"Chiral drugs: an overview","volume":"2","author":"Nguyen LA","year":"2006","journal-title":"International Journal of Biomedical Science: IJBS"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.02.037"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.115807"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201302823"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.10.022"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2020.461244"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2020.461286"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.06.011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10337\u2010018\u20103526\u20100"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109673(94)80400\u20101"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2019.07.011"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/30.3.67"},{"key":"e_1_2_8_15_1","volume-title":"Chromatographic enantioseparation","author":"Allenmark SG","year":"1988"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731\u20107085(01)00652\u20105"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20104347(99)00307\u20102"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.07.008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.116090"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010158"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5334\/tohm.165"},{"issue":"2","key":"e_1_2_8_22_1","first-page":"1","article-title":"American Psychiatric Association practice guidelines; work group on schizophrenia. 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