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This critical review examines analytical techniques for the enantioselective separation and determination of IBP enantiomers, crucial for pharmaceutical and clinical applications. The review focuses on state\u2010of\u2010the\u2010art methods, including chromatographic techniques including high\u2010performance liquid chromatography, gas chromatography, liquid chromatography\u2013tandem mass spectrometry, and some other techniques. This review addresses pharmacokinetics, pharmacology, and side effects of each enantiomer, ensuring safe drug usage. By consolidating diverse analytical methods and their applicability in different matrices, this review serves as a valuable resource for researchers, analysts, and practitioners in pharmaceutical analysis, pharmacology, and clinical studies.<\/jats:p>","DOI":"10.1002\/chir.23647","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T05:49:35Z","timestamp":1707976175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-5297","authenticated-orcid":false,"given":"Vinod Kumar","family":"Vashistha","sequence":"first","affiliation":[{"name":"Department of Chemistry GLA University  Mathura India"},{"name":"Department of Chemistry University of Lucknow  Lucknow 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