{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T16:32:09Z","timestamp":1763224329814,"version":"3.41.2"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["RSP2024R1"],"award-info":[{"award-number":["RSP2024R1"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Due to a great demand for amylose and cellulose polymeric chromatographic chiral columns, the enantiomeric separation of thiourea derivatives of naringenin was achieved on the different amylose (Chiralpak\u2010IB) and cellulose chiral (Chiralcel\u2010OJ and Chiralcel\u2010OD\u20103R) columns with varied chromatographic conditions. The isocratic mobile phases used were ethanol and methanol, where ethanol\/hexane and methanol\/hexane were used as gradient mode and were prepared in volume\/volume relation. The separation and resolution factors for all the enantiomers were in the range of 1.25 to 3.47 and 0.48 to 1.75, respectively. The enantiomeric resolution was obtained within 12\u2009min making fast separation. The docking studies confirmed the chiral recognition mechanisms with binding affinities in the range of \u22124.7 to \u22125.7\u2009kcal\/mol. The reported compounds have good anticoagulant activities and may be used as anticoagulants in the future. Besides, chiral separation is fast and is useful for enantiomeric separation in any laboratory in the world.<\/jats:p>","DOI":"10.1002\/chir.23659","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T08:50:39Z","timestamp":1709715039000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Enantiomeric separation of thiourea derivatives of naringenin on amylose and cellulose polymeric chromatographic chiral columns"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-8374","authenticated-orcid":false,"given":"Imran","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Chemistry Jamia Millia Islamia (Central University)  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rekia","family":"Nabti","sequence":"additional","affiliation":[{"name":"Bioactive Molecules and Chiral Separation Laboratory, Faculty of Exact Sciences Tahri Mohammed's University  B\u00e9char Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Belboukhari","sequence":"additional","affiliation":[{"name":"Bioactive Molecules and Chiral Separation Laboratory, Faculty of Exact Sciences Tahri Mohammed's University  B\u00e9char Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-5144","authenticated-orcid":false,"given":"Khaled","family":"Sekkoum","sequence":"additional","affiliation":[{"name":"Bioactive Molecules and Chiral Separation Laboratory, Faculty of Exact Sciences Tahri Mohammed's University  B\u00e9char Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed El Amin","family":"Zaid","sequence":"additional","affiliation":[{"name":"Bioactive Molecules and Chiral Separation Laboratory, Faculty of Exact Sciences Tahri Mohammed's University  B\u00e9char Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khairedine","family":"Kraim","sequence":"additional","affiliation":[{"name":"Higher Normal School of Technological Education of Skikda (ENSET)  Skikda Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9970-2480","authenticated-orcid":false,"given":"Zeid A.","family":"ALOthman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University \u201cG. d'Annunzio\u201d of Chieti\u2010Pescara  Chieti 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