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The corresponding\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010hydroxytetrazole was isolated in 60% yield and &gt;98% ee. This is the first report on the biocatalytic reduction of\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010ketotetrazole using plant enzymes derived from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>D.\u00a0carota<\/jats:italic>\n                    <\/jats:styled-content>\n                    root cells with excellent enantioselectivity.\n                  <\/jats:p>","DOI":"10.1002\/chir.23660","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T08:58:36Z","timestamp":1711011516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Biocatalytic enantioselective synthesis of cenobamate, an antiepileptic drug"],"prefix":"10.1002","volume":"36","author":[{"given":"Vennapusa","family":"Haritha","sequence":"first","affiliation":[{"name":"Research Scholar Jawaharlal Nehru Technological University Anantapur  Ananthapuramu India"},{"name":"Fluoro\u2010Agrochemicals CSIR\u2010Indian Institute of Chemical Technology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pulivarthi","family":"Deepthi","sequence":"additional","affiliation":[{"name":"Fluoro\u2010Agrochemicals CSIR\u2010Indian Institute of Chemical Technology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Gundamalla","sequence":"additional","affiliation":[{"name":"Fluoro\u2010Agrochemicals CSIR\u2010Indian Institute of Chemical Technology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kommu","family":"Nagesh","sequence":"additional","affiliation":[{"name":"Fluoro\u2010Agrochemicals CSIR\u2010Indian Institute of Chemical Technology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suggala V.","family":"Satyanarayana","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, JNTUA College of Engineering, Ananthapuramu Constituent College of Jawaharlal Nehru Technological University Anantapur  Ananthapuramu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3465-6476","authenticated-orcid":false,"given":"Adari Bhaskar","family":"Rao","sequence":"additional","affiliation":[{"name":"Fluoro\u2010Agrochemicals CSIR\u2010Indian Institute of Chemical Technology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sridhar","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Center for X\u2010ray Crystallography CSIR\u2010Indian Institute of Chemical Technology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0814-583X","authenticated-orcid":false,"given":"Basireddy Venkata Subba","family":"Reddy","sequence":"additional","affiliation":[{"name":"Fluoro\u2010Agrochemicals CSIR\u2010Indian Institute of Chemical Technology  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2008.09.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.05.007"},{"issue":"15","key":"e_1_2_7_4_1","first-page":"278","article-title":"Mechanism of action of cenobamate: preferential inhibition of the persistent sodium current","volume":"90","author":"Nakamura M","year":"2018","journal-title":"Neurology"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2015.01.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00208"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(19)30399\u20100"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010019\u20100309\u20107"},{"key":"e_1_2_7_6_3","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2020.1803830"},{"key":"e_1_2_7_7_1","unstructured":"(a)ChoiYM KimCG KangYS et al.Neurotherapeutic azole compounds. 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