{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:38:08Z","timestamp":1790987888481,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,9,21]],"date-time":"2004-09-21T00:00:00Z","timestamp":1095724800000},"content-version":"vor","delay-in-days":5377,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies to characterize the pharmacokinetics of the enantiomers of MDMA were conducted in rats using the iliac arterial cannulation. Two routes of administration, intravenous and subcutaneous, were evaluated at two dose levels for each route [20 and 40 mg\/kg (\u00b1)\u2010MDMA for subcutaneous, 10 and 20 mg\/kg (\u00b1)\u2010MDMA for intravenous administrations]. The average half\u2010life (\u00b1SD) for all dosing groups was 2.5 \u00b1 0.8 h for (\u2212)\u2010(R)\u2010MDMA and 2.2 \u00b10.8 h for (+)\u2010(S)\u2010MDMA. The more rapid clearnace of (+)\u2010(S)\u2010MDMA compared with (\u2212)\u2010(R)\u2010MDMA is consistent with the area under the curve (AUC) data of the parent drug and its primary metabolite MDA. The mean (\u00b1SD) AUC S\/R ratios of MDMA and MDA were 0.70 \u00b1 0.05 and 3.1 \u00b1 0.8, respectively. Following a 20 mg\/kg dose of racemic MDMA iv the mean (\u00b1SD) of the percent dose excreted as (\u2212)\u2010(R)\u2010MDMA, (+)\u2010(S)\u2010MDMA, (\u2212)\u2010(R)\u2010MDA, and (+)\u2010(S)\u2010MDA were 20 \u00b1 10, 12 \u00b1 6, 3 \u00b1 1, and 6 \u00b1 2, respectively.<\/jats:p>","DOI":"10.1002\/chir.530020409","type":"journal-article","created":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T10:04:16Z","timestamp":1105092256000},"page":"241-248","source":"Crossref","is-referenced-by-count":28,"title":["Stereoselective pharmacokinetics of 3,4\u2010methylenedioxymethamphetamine in the rat"],"prefix":"10.1002","volume":"2","author":[{"given":"Robert L.","family":"Fitzgerald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert V.","family":"Blanke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alphonse","family":"Poklis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,9,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(86)90140-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(88)90285-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/jama.1988.03410010059035","article-title":"\u00b13,4\u2010methylenedioxymethamphetamine selectively damages central serotonergic neurons in nonhuman primates","volume":"260","author":"Ricaurte G.A.","year":"1988","journal-title":"J. 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