{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:26:49Z","timestamp":1760887609321},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,9,21]],"date-time":"2004-09-21T00:00:00Z","timestamp":1095724800000},"content-version":"vor","delay-in-days":4281,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chirality"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010performance capillary electrophoresis (HPCE) and micellar electrokinetic capillary chromatography (MECC) were applied to the resolution of racemic nonsteroidal antiaromatase drugs and intermediates. Successful results were obtained in both modes using \u03b1\u2010cyclodextrin (\u03b1\u2010CD), \u03b2\u2010cyclodextrin (\u03b2\u2010CD), \u03b3\u2010cyclodextrin (\u03b3\u2010CD), or 2,6\u2010di\u2010<jats:italic>O<\/jats:italic>\u2010methyl\u2010\u03b2\u2010cyclodextrin (DM\u2010\u03b2\u2010CD) as chiral selectors. Depending on the structure of the solute, one of the cyclodextrins was generally better suited for resolution of the racemate. The basic solutes were analyzed under HPCE conditions, whereas the nonionizable compounds such as glutethimide (Doriden\u00ae) were analyzed in MECC mode. For the azole\u2010type antiaromatase Fadrozole, both HPCE and MECC modes could be used to achieve the separation of the enantiomers. The influence of experimental factors such as pH, the presence of organic modifier, temperature, the micelle concentration, and the concentration of the chiral selector is also discussed on the basis of the results obtained with some chiral barbiturates. The possibility of analyzing the enantiomers directly in plasma samples was also demonstrated. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/chir.530050708","type":"journal-article","created":{"date-parts":[[2005,1,7]],"date-time":"2005-01-07T14:37:00Z","timestamp":1105108620000},"page":"516-526","source":"Crossref","is-referenced-by-count":43,"title":["Separation of the enantiomers of some racemic nonsteroidal aromatase inhibitors and barbiturates by capillary electrophoresis"],"prefix":"10.1002","volume":"5","author":[{"given":"Eric","family":"Francotte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Cherkaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Faupel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,21]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Chiral Separations by HPLC","author":"Krstulovic A.M.","year":"1989"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(92)80172-M"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)80145-K"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)84564-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)87150-7"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2318(08)60167-5"},{"key":"e_1_2_1_8_2","first-page":"208","volume-title":"Chiral Separation by HPLC","author":"Haan S.M.","year":"1989"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(83)90068-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00062a012"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/10826079208018848"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)88522-8"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)88738-0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/chir.530040112"},{"key":"e_1_2_1_15_2","unstructured":"Persson G. Palmarsdottir S. Walhagen A. Edholm L.\u2010E.Chiral separation of drug enantiomers using capillary electrophoresis and cyclodextrins as chiral selectors and application to bioanalysis. Poster presentation at the 15th Symposium on Column Liquid Chromatography Basel (Switzerland) 3\u20137 June 1991."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)93941-X"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(93)80067-I"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)85366-2"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02290453"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm00400a014"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00324763"},{"key":"e_1_2_1_22_2","volume-title":"The Pharmacological Basis of Therapeutics","author":"Goodman L.S.","year":"1970"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600600444"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00662237"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02276847"},{"key":"e_1_2_1_26_2","unstructured":"Heuermann M. Blaschke G.Application of cyclodextrin\u2010modified HPCE to the chiral analysis of racemic drugs. Poster presented at the 3rd Symposium on chiral discrimination T\u00fcbingen (Germany) 4\u20137 October 1992."},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)85246-P"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(92)80181-S"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2670(00)83323-1"}],"container-title":["Chirality"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fchir.530050708","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chir.530050708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T12:23:17Z","timestamp":1698236597000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/chir.530050708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/chir.530050708"],"URL":"https:\/\/doi.org\/10.1002\/chir.530050708","archive":["Portico"],"relation":{},"ISSN":["0899-0042","1520-636X"],"issn-type":[{"value":"0899-0042","type":"print"},{"value":"1520-636X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}