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The resin was developed through the condensation polymerization of p\u2010hydroxybenzoic acid (4\u2010HBA) and 4\u2010nitrophenol (4\u2010NP) with formaldehyde in an acidic medium. The resultant polymer was reduced to introduce amino groups into the polymer to obtain a dual\u2010functional resin with amino and carboxylic groups (CA\u2010P). After the uptake of S\u2010VF, glutaraldehyde cross\u2010linking stabilized the resin and formed its enantioselective cavities. Adsorption studies showed that optimum conditions occurred at pH\u20097, whereas the maximum adsorption capacity was 420\u2009mg\/g according to the Langmuir isotherm. The selectivity coefficient of S\u2010VF\u2010IP was 13 times that of NIP, confirming that the imprinting process indeed occurred. Chiral separation experiments using the SV\u2010imprinted polymer (S\u2010VF\u2010IP) column resulted in 98% enantiomeric excess for R\u2010VF, whereas the respective NIP did not provide any enantioselectivity. These results show a great possibility of the developed resin in efficient enantioselective separation and offer a promising method for the purification of chiral drugs from racemic mixtures in pharmaceutical applications.<\/jats:p>","DOI":"10.1002\/chir.70023","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T05:34:12Z","timestamp":1739856852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development of Acid\u2010Functionalized Molecularly Imprinted Phenolic Resin for Chiral Recognition of S\u2010Venlafaxine"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3227-3965","authenticated-orcid":false,"given":"Rua\u00a0B.","family":"Alnoman","sequence":"first","affiliation":[{"name":"Chemistry Department, Faculty of Science Taibah University  Yanbu Saudi 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