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After having optimized the reaction conditions and tested different amino residues, the best catalyst was tested in ATH of various aromatic ketones, leading to generally high yields (up to &gt;\u200995%) and moderate to good enantioselectivities (<jats:italic>ee<\/jats:italic> 24%\u201369%). Moreover, considering the lack of examples of recoverable and reusable amino alcohol\u2013based nanostructured catalysts for the ATH, the catalyst of choice was immobilized on proper functionalized superparamagnetic core\u2013shell magnetite\u2013silica nanoparticles and employed in an ATH reaction in semi\u2010homogeneous phase. The obtained nanocatalyst exhibited a moderate catalytic efficiency in the ATH, that remains unchanged in the three catalytic cycles performed, even if noticeably worse than in the homogeneous counterpart.<\/jats:p>","DOI":"10.1002\/chir.70031","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:13:01Z","timestamp":1741752781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of New Chiral Amino Alcohol Ligand for the Asymmetric Transfer Hydrogenation of Ketones and Its Immobilization Onto Nanomaterials for an Ease of Recovery and Reuse"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-6091","authenticated-orcid":false,"given":"Ludovica","family":"Primitivo","sequence":"first","affiliation":[{"name":"Department of Chemistry \u201cSapienza\u201d University of Rome  Rome 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