{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:28:08Z","timestamp":1755793688120,"version":"3.44.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Ketoprofen, also known as (RS)\u20102\u2010(3\u2010benzoylphenyl)\u2010propionic acid, has the molecular formula C<jats:sub>16<\/jats:sub>H<jats:sub>14<\/jats:sub>O<jats:sub>3<\/jats:sub> and is classified as a non\u2010steroidal anti\u2010inflammatory medication. R\u2010ketoprofen has stronger analgesic effects than S\u2010K, and as a result, there is a growing interest in enantio\u2010recognition research, which may be accomplished through supramolecular interactions, particularly host\u2010guest reactions. A 1:1 molar ratio was used to produce the combination of separate RK and SK and a 0.01\u2009M stock solution of HP\u2010\u03b2\u2010CD to get the final concentration of 6\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>\u2009M. Ethanol was used to make stock solutions of ketoprofen enantiomers (1\u2009mM). Researchers combined a specific volume of ketoprofen with 2\u2010hydroxypropyl\u2010beta\u2010cyclodextrin (HP\u03b2\u2010CD) and then used spectroscopic methods to study how the S\u2010ketoprofen (SK) and R\u2010ketoprofen (RK) enantiomers interact with HP\u03b2\u2010CD to form inclusion complexes in an aqueous solution. The Benesi\u2013Hildebrand plot was used to determine the inclusion complexes' stoichiometry ratio and binding constant; both enantiomers displayed a 1:1 stoichiometry ratio inclusion complex with HP\u2010\u03b2\u2010CD. Compared with SK (799\u2009M<jats:sup>\u22121<\/jats:sup>), RK has a higher binding constant (1038\u2009M<jats:sup>\u22121<\/jats:sup>). These results showed that HP\u2010\u03b2\u2010CD preferred to form inclusion complexes with RK over SK. At neutral pH, there are significant differences between RK and SK when HP\u2010\u03b2\u2010CD is present.<\/jats:p>","DOI":"10.1002\/chir.70045","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T12:24:57Z","timestamp":1755001497000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spectroscopic Study of R\u2010 and S\u2010Ketoprofen Inclusion Complexes With 2\u2010Hydroxypropyl\u2010\u03b2\u2010cyclodextrin"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3840-7757","authenticated-orcid":false,"given":"Asma","family":"Obaid","sequence":"first","affiliation":[{"name":"Department of Physical Sciences, Chemistry Division, College of Science Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nujud","family":"Maslamani","sequence":"additional","affiliation":[{"name":"Department of Physical Sciences, Chemistry Division, College of Science Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameerah","family":"Theqah","sequence":"additional","affiliation":[{"name":"Department of Physical Sciences, Chemistry Division, College of Science Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hind","family":"Siddiq","sequence":"additional","affiliation":[{"name":"Department of Physical Sciences, Chemistry Division, College of Science Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem","family":"Ghubayra","sequence":"additional","affiliation":[{"name":"Department of Physical Sciences, Chemistry Division, College of Science Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibtisam","family":"Mousa","sequence":"additional","affiliation":[{"name":"Department of Physical Sciences, Chemistry Division, College of Science Jazan University  Jazan Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arniza\u00a0Khairani\u00a0Mohd","family":"Jamil","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siti\u00a0Munirah","family":"Saharin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Centre for Ionic Liquids University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharifah","family":"Mohamad","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11030361"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251810126"},{"volume-title":"Nonsteroidal Anti\u2010Inflammatory Drugs: Concepts and Innovations. 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O.Obaid H.Siddiq A. K. M.Jamil S. 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