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Among the solvents investigated, ethyl acetate was identified as the optimal solvent, allowing rapid crystallization and high enantiomeric purity (&gt;\u200999% <jats:italic>ee<\/jats:italic>). A detailed study of kinetic behavior revealed that early\u2010stage crystallization and timely separation of diastereomeric salt are critical to achieving high enantiopurity and avoiding recrystallization to lead to a racemic product. Time\u2010dependent studies suggest that solvate formation of enantiomers and ethyl acetate plays a crucial role in the resolution mechanism. This resolution process enables the direct separation of racemic 2\u2010(2\u2010carbamoyl\u20101<jats:italic>H<\/jats:italic>\u2010pyrrol\u20101\u2010yl)\u20103\u2010(trifluoromethyl) benzoic acid suitable for further applications, such as resolving agents for amine\u2010type compounds. Significantly, this approach recycles an amine\u2010type drug intermediate that is typically discarded during the large\u2010scale production of Apremilast, thus being in line with green chemistry principles by minimizing waste and enabling resource recovery.<\/jats:p>","DOI":"10.1002\/chir.70054","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T11:13:37Z","timestamp":1759317217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time\u2010Dependent Resolution of an Atropisomeric 1\u2010Arylpyrrole by a Novel 1\u2010Arylethylamine Saltforming Agent"],"prefix":"10.1002","volume":"37","author":[{"given":"Hong\u00a0Ha\u00a0Thuy","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5107-7089","authenticated-orcid":false,"given":"Erika","family":"B\u00e1lint","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8782-7972","authenticated-orcid":false,"given":"B\u00e9la","family":"M\u00e1trav\u00f6lgyi","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics  Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/app122110909"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02239"},{"issue":"3","key":"e_1_2_7_4_1","first-page":"242","article-title":"Importance of Chirality in Drug Therapy and Pharmacy Practice: Implications for Psychiatry","volume":"1","author":"Davies N. 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