{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:39:23Z","timestamp":1788406763260,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this work, a CDs\u2010TpBD\/UiO\u201066 hybrid material was firstly synthesized via Schiff base reaction using isocyanate\u2010\u03b2\u2010cyclodextrin (CDs) as a chiral modifier, TpBD COF and UiO\u201066\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    MOF as the frameworks, and was characterized by Fourier\u2010transform infrared spectra, scanning\/transmission electron microscopy, X\u2010ray diffraction spectra, X\u2010ray photoelectron spectroscopy, nitrogen adsorption\u2013desorption, and thermogravimetric analysis. The results showed that the hybrid material exhibited a close\u2010packed structure of TpBD and UiO\u201066\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    crystal, well\u2010defined micropores, and good stability. It was used as the stationary phase in open\u2010tubular (OT) capillary electrochromatography, and 7 amino acids (basic: D\/L\u2010arginine, D\/L\u2010histidine, D\/L\u2010lysine; neutral: D\/L\u2010methionine, D\/L\u2010valine; acidic: D\/L\u2010aspartate, D\/L\u2010glutamic acid) and D\/L\u2010carnitine (D\/L\u2010Car) were baseline separated under the optimal chromatographic conditions within 6\u2009min by capillary electrochromatography. The resolution (Rs) ranged from 1.50 to 5.41, and the selectivity factor (\u03b1) ranged from 1.08 to 2.52, respectively. Enantioseparation was attributed to the synergistic effect of CDs, TpBD, and UiO\u201066\u2010NH\n                    <jats:sub>2<\/jats:sub>\n                    in the stationary phase as well as the difference of adsorption and selectivity between the enantiomers and the stationary phase through the adsorption experiments. The detection method of D\/L\u2010Car was established by CDs\u2010TpBD\/UiO\u201066 OT column. Good linearity (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009\u2265\u20090.999) was obtained in the concentration ranges of 8.5\u2013200\u2009\u03bcg\/mL for D\u2010Car and 7.0\u2013200\u2009\u03bcg\/mL for L\u2010Car with detection limits of 2.5 and 2.1\u2009\u03bcg\/mL, respectively. The developed method was simple, rapid, high efficiency as well as broad application, and could be applied for the simultaneous separation and detection of D\/L\u2010Car in actual samples.\n                  <\/jats:p>","DOI":"10.1002\/chir.70059","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T08:12:37Z","timestamp":1762589557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enantioseparation and Determination for Racemate Carnitine Based on a Chiral Hybrid Material Synthesized by Metal Organic Framework and Covalent Organic Framework in Capillary Electrochromatography"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4933-5417","authenticated-orcid":false,"given":"Jiawen","family":"Yu","sequence":"first","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qiqihar University  Qiqihar China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidi","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qiqihar University  Qiqihar China"},{"name":"Heilongjiang Industrial Hemp Processing Technology Innovation Center Qiqihar University  Qiqihar China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Qu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qiqihar University  Qiqihar China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0049-4731","authenticated-orcid":false,"given":"Mo","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qiqihar University  Qiqihar China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qiqihar University  Qiqihar China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qiqihar University  Qiqihar China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qiqihar University  Qiqihar China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Chu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qiqihar University  Qiqihar China"},{"name":"Heilongjiang Industrial Hemp Processing Technology Innovation Center Qiqihar University  Qiqihar China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4853-803X","authenticated-orcid":false,"given":"Shili","family":"Qin","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering Qiqihar University  Qiqihar China"},{"name":"Heilongjiang Industrial Hemp Processing Technology Innovation Center Qiqihar University  Qiqihar China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuren","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Interdisciplinary Research Academy (IRA) Zhejiang Shuren University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"issue":"12","key":"e_1_2_7_2_1","first-page":"1469","article-title":"Stereopharmacology of Carnitine","volume":"91","author":"Spasov A. 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