{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T08:26:08Z","timestamp":1765787168594,"version":"3.48.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177044"],"award-info":[{"award-number":["22177044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009590","name":"Gansu Education Department","doi-asserted-by":"publisher","award":["2024B\u2010058"],"award-info":[{"award-number":["2024B\u2010058"]}],"id":[{"id":"10.13039\/501100009590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017702","name":"Innovation and Entrepreneurship Talent Project of Lanzhou","doi-asserted-by":"publisher","award":["2022\u2010RC\u201045"],"award-info":[{"award-number":["2022\u2010RC\u201045"]}],"id":[{"id":"10.13039\/501100017702","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Two previously undescribed jatrophane\u2010type diterpenoids (\n 1<\/jats:bold>\n ,\n 2<\/jats:bold>\n ) and 11 known compounds (\n 3<\/jats:bold>\n \u2013\n 13<\/jats:bold>\n ) were isolated from the whole plants of\n \n Jatropha curcas<\/jats:italic>\n <\/jats:styled-content>\n L. Their structures were elucidated using IR, HR\u2010ESI\u2010MS, 1D\u2010, and 2D\u2010NMR spectra, and the absolute configurations were established by ECD. The anti\u2010inflammatory activity of these compounds was evaluated by inhibiting NO production in LPS\u2010stimulated RAW264.7 macrophages, and compounds\n 5<\/jats:bold>\n ,\n 8<\/jats:bold>\n \u2013\n 11,<\/jats:bold>\n and\n 13<\/jats:bold>\n showed potent activity with IC\n 50<\/jats:sub>\n values ranging from 16.86 to 32.49\u2009\u03bcM, which were comparable with that of the positive control\n l<\/jats:sc>\n \u2010NMMA (IC\n 50<\/jats:sub>\n : 21.90\u2009\u03bcM). The structure\u2013activity relationships of jatrophane\u2010type diterpenoids revealed that compounds\n 5<\/jats:bold>\n and\n 11<\/jats:bold>\n showed the most potent anti\u2010inflammatory effects.\n <\/jats:p>","DOI":"10.1002\/chir.70061","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T04:42:21Z","timestamp":1764045741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Inflammatory Jatrophane Diterpenoids With Multiple Chiral Carbon Centers From\n \n Jatropha curcas<\/i>\n <\/scp>"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6494-3486","authenticated-orcid":false,"given":"Yi\u2010Lin","family":"He","sequence":"first","affiliation":[{"name":"Research Institute, School of Chemistry and Chemical Engineering Lanzhou Jiaotong University Lanzhou China"},{"name":"State Key Laboratory of Nature Product Chemistry, College of Chemistry and Chemical Engineering Lanzhou University Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo\u2010Li","family":"Li","sequence":"additional","affiliation":[{"name":"Research Institute, School of Chemistry and Chemical Engineering Lanzhou Jiaotong University Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Institute, School of Chemistry and Chemical Engineering Lanzhou Jiaotong University Lanzhou China"},{"name":"State Key Laboratory of Nature Product Chemistry, College of Chemistry and Chemical Engineering Lanzhou University Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Gao","sequence":"additional","affiliation":[{"name":"Research Institute, School of Chemistry and Chemical Engineering Lanzhou Jiaotong University Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Nature Product Chemistry, College of Chemistry and Chemical Engineering Lanzhou University Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.108976"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105222"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5b03473"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.6b00206"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2024.114369"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.7b00233"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113420"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.1c01050"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201700327"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2007.05.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2024.106331"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00605"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/np070174v"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400541j"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2020.112649"}],"container-title":["Chirality"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/chir.70061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T08:23:44Z","timestamp":1765787024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/chir.70061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/chir.70061"],"URL":"https:\/\/doi.org\/10.1002\/chir.70061","archive":["Portico"],"relation":{},"ISSN":["0899-0042","1520-636X"],"issn-type":[{"type":"print","value":"0899-0042"},{"type":"electronic","value":"1520-636X"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"2025-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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