{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:06:10Z","timestamp":1790111170263,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The objective of this study was to investigate the biotransformation characteristics and stereoselective pharmacokinetic profiles of ibuprofen (IBU) enantiomers following administration of single isomers or a racemic mixture in rats, mice, and guinea pigs. A chiral LC\u2010MS\/MS method was employed to simultaneously determine (R)\u2010(\u2212)\u2010ibuprofen and (S)\u2010(+)\u2010ibuprofen in trace whole blood samples (5\u2009\u03bcL). Enantiomeric inversion of IBU was assessed after separate administration of single isomers or the racemic mixture, and pharmacokinetic parameters were calculated. Results demonstrated significantly higher AUC\n                    <jats:sub>last<\/jats:sub>\n                    values for the S\u2010enantiomer compared to the R\u2010enantiomer. Unidirectional enantiomeric inversion from R\u2010IBU to S\u2010IBU was observed in all tested species (rats, mice, and guinea pigs), with no reverse conversion detected. Notably, this study is the first to confirm strictly unidirectional enantiomeric inversion of IBU in guinea pigs. Conversion rates calculated from R\u2010IBU and S\u2010IBU concentrations following racemic IBU administration exhibited significant interspecies differences: 54.9\u2009\u00b1\u20095.6% (rats), 76.6\u2009\u00b1\u20095.3% (mice), and 65.6\u2009\u00b1\u20096.7% (guinea pigs). In contrast, no significant species differences were observed when conversion rates were derived from S\u2010IBU concentrations after administration of individual enantiomers (R\u2010IBU and S\u2010IBU), yielding values of 65.9\u2009\u00b1\u20096.5%, 76.8\u2009\u00b1\u200921.2%, and 66.3\u2009\u00b1\u200914.4% for rats, mice, and guinea pigs, respectively.\n                  <\/jats:p>","DOI":"10.1002\/chir.70081","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T02:01:06Z","timestamp":1767751266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Stereoselective Pharmacokinetics of Ibuprofen Enantiomers in Mice, Guinea Pigs, and Rats"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9144-6723","authenticated-orcid":false,"given":"Huanhuan","family":"Yang","sequence":"first","affiliation":[{"name":"Guollence Pharmaceutical Technology Co. Ltd.  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2551-8383","authenticated-orcid":false,"given":"Yuexin","family":"Li","sequence":"additional","affiliation":[{"name":"Guollence Pharmaceutical Technology Co. Ltd.  Beijing China"},{"name":"School of Pharmacy Shenyang Pharmaceutical University  Benxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Xu","sequence":"additional","affiliation":[{"name":"Chinese PAP Force Hospital of Beijing  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8970-5216","authenticated-orcid":false,"given":"Jinglai","family":"Li","sequence":"additional","affiliation":[{"name":"Guollence Pharmaceutical Technology Co. Ltd.  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