{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:46:45Z","timestamp":1775731605978,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Drug development by derivatization is one of the most important research areas. Fifteen derivatives of ibuprofen were synthesized to overcome the side effects of this medicine. The derivatives were characterized by FT\u2010IR, NMR, and mass spectroscopy. These derivatives are racemic mixtures, and the chiral separation was achieved on Lux Cellulose\u20101 (250\u2009\u00d7\u20094.6\u2009mm, 5\u2009\u03bcm) using various mobile phases of methanol\u2013water and acetonitrile\u2010water. All the racemates have been resolved successfully with the best separations of 2, 11, and 15 derivatives with maximum resolution factors of 8.94 and 13.72 with mobile phases methanol\u2013water (90:10, v\/v) and acetonitrile\u2010water (80:20, v\/v). The chiral recognition was determined by a modeling approach, confirming that the R\u2010enantiomer elution first, followed by the S\u2010enantiomer. The biological evaluation of these derivatives was carried out by modeling of R\u2010 and S\u2010enantiomers with COX\u2010II enzyme. It was determined that all the derivatives had greater binding affinities with COX\u2010II in comparison to ibuprofen, confirming better efficacy of these derivatives. Besides, the maximum binding affinities of 2, 11, and 15 derivatives were \u22126.4 and \u22127.0; \u22127.2 and 7.5; and \u22127.8 and 8.4\u2009kcal\/mol for R\u2010 and S\u2010enantiomers, respectively. This clearly indicates that S\u2010enantiomers of these derivatives will be better medications in the future.<\/jats:p>","DOI":"10.1002\/chir.70085","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T01:55:03Z","timestamp":1768614903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Chiral Separations of Ibuprofen Derivatives for Increased Anti\u2010Inflammatory Activities"],"prefix":"10.1002","volume":"38","author":[{"given":"Mohd","family":"Mustaqeem","sequence":"first","affiliation":[{"name":"Department of Chemistry Jamia Millia Islamia  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Gogolashvili","sequence":"additional","affiliation":[{"name":"School of Education Caucasus University  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lali","family":"Chankvetadze","sequence":"additional","affiliation":[{"name":"Tbilisi State University  Tbilisi Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-5144","authenticated-orcid":false,"given":"Khaled","family":"Sekkoum","sequence":"additional","affiliation":[{"name":"Bioactive Molecules &amp; Chiral Separation Laboratory, Faculty of Exact Sciences Tahri Mohamed University\u2010Bechar  B\u00e9char Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouslim","family":"Messali","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science Imam Mohammad Ibn Saud Islamic University (IMSIU)  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-8374","authenticated-orcid":false,"given":"Imran","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Chemistry Jamia Millia Islamia  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"13","article-title":"Review of the Analgesic Efficacy of Ibuprofen","volume":"135","author":"Beaver W. 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