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However, most synthetic methods produce racemic mixtures, making efficient strategies for enantioseparation and chiral amplification essential. Among the available approaches, crystallization\u2010based methods offer scalable and mechanistically versatile routes for controlling chirality in the solid state. This review summarizes recent advances in solid\u2010state crystallization strategies for chiral resolution, chirality generation, and enantiomeric amplification. Emphasis is placed on the structural and thermodynamic factors governing the formation of racemic compounds, conglomerates, and solid solutions, and how these phase behaviors influence separation outcomes. 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By integrating representative examples with broader conceptual analysis, this review outlines key design principles governing chiral outcomes in crystalline systems and highlights expanding applications of chiral co\u2010crystals in pharmaceuticals and as functional materials, providing a framework for future advances in crystallization\u2010mediated chirality control.<\/jats:p>","DOI":"10.1002\/chir.70100","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:04:26Z","timestamp":1776643466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Engineering Chirality in the Solid State: Co\u2010Crystallization as a Strategy for Chiral Induction and Resolution"],"prefix":"10.1002","volume":"38","author":[{"given":"Ramamohana\u00a0Reddy","family":"Maddike","sequence":"first","affiliation":[{"name":"BPI Labs LLC  Largo Florida 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