{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:02:51Z","timestamp":1789441371963,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chirality remains a central yet inconsistently operationalized concept in pharmaceutical analysis. Although regulatory frameworks emphasize stereochemical characterization and enantiomeric control, practical analytical decisions are often guided by expert intuition and historical precedent. These include determining when chiral separation is necessary, when achiral methods are sufficient, and how to balance analytical rigor with analytical complexity. With increasing molecular complexity, accelerated development timelines, and heightened regulatory expectations, such intuition\u2010driven approaches face growing limitations. Artificial intelligence (AI) has emerged as a powerful enabler across pharmaceutical sciences; however, its role in chiral decision\u2010making has not been systematically articulated. This perspective reframes chirality as a decision\u2010driven discipline and proposes a concept\u2010driven, framework\u2010oriented approach in which AI functions as a cognitive decision\u2010support layer rather than a replacement for stereochemical expertise. It integrates stereochemistry, decision science, explainable artificial intelligence (XAI), and regulatory reasoning into a coherent approach for chiral decision\u2010making in pharmaceutical analysis. Unlike existing AI applications that primarily focus on analytical optimization, this perspective proposes a decision\u2010oriented framework for evaluating when chiral analysis is warranted and how analytical decisions may be supported using multidisciplinary evidence. The proposed framework bridges traditional stereochemical reasoning with data\u2010driven intelligence and provides a structured basis for future chiral decision\u2010support systems. As a framework\u2010oriented perspective, this work is intended to stimulate discussion and guide future empirical evaluation, including prototype decision\u2010support systems, curated datasets, and prospective validation studies, rather than present a validated AI implementation.<\/jats:p>","DOI":"10.1002\/chir.70133","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:30:12Z","timestamp":1789133412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rethinking Chiral Decision\u2010Making in Pharmaceutical Analysis: The Emerging Role of Artificial Intelligence"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7537-8766","authenticated-orcid":false,"given":"Sivakumar","family":"Thanikachalam","sequence":"first","affiliation":[{"name":"Independent Researcher  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0276-439X","authenticated-orcid":false,"given":"Valliappan","family":"Kannappan","sequence":"additional","affiliation":[{"name":"Chiralpedia  Coimbatore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00541922"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600780902"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109673(95)00465\u20103"},{"key":"e_1_2_13_5_1","first-page":"7","article-title":"The Chiral Switch: Development of Single\u2010Enantiomer Drugs From Racemates","volume":"50","author":"Hutt A.","year":"2003","journal-title":"Acta Facultatis Pharmaceuticae Universitatis Comenianae"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359\u20106446(99)01363\u2010X"},{"key":"e_1_2_13_7_1","volume-title":"Development of New Stereoisomeric Drugs","author":"U.S. Food and Drug Administration","year":"1992"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp097"},{"key":"e_1_2_13_9_1","volume-title":"ICH Q6A: Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances","author":"International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH)","year":"1999"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd915"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163\u20107258(90)90069\u2010E"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.59566\/IJBS.2006.2085"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.5530\/001954640002"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14539"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010019\u20100024\u20105"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.70066"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/B1RP90014E"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359\u20106446(03)02904\u20100"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1386207326666230102123655"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02239"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa8415"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.232"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.01.039"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100300\u20107"},{"key":"e_1_2_13_25_1","volume-title":"The Tacit Dimension","author":"Polanyi M.","year":"1966"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010933404324"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1145\/3236009"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248\u2010014\u20109598\u20103"},{"key":"e_1_2_13_29_1","volume-title":"ICH Q9: Quality Risk Management","author":"International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH)","year":"2005"},{"key":"e_1_2_13_30_1","unstructured":"W.SamekandK. 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