{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:02:44Z","timestamp":1789441364611,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A new enantioselective molecularly imprinted polymer (MIP) was developed for recognizing S\u2010ketorolac (S\u2010KR), a model chiral acidic drug. The synthetic process started with a resorcinol\u2010formaldehyde resin (RSF), which was cyanoethylated under phase\u2010transfer catalytic conditions to obtain RSF\u2010CN. Then, the nitrile groups turned into cationic\/basic hydrazidine sites after reacting with hydrazine hydrate, resulting in RSF\u2010HD. Next, S\u2010KR was interacted with RSF\u2010HD in a DMF\/water solution at pH\u20097, before adding glutaraldehyde for post\u2010crosslinker. After that, the S\u2010KR template was removed to get the final S\u2010KR\u2010imprinted polymer (S\u2010KR\u2010P). Tests, such as elemental analysis and solid\u2010state\n                    <jats:sup>13<\/jats:sup>\n                    C NMR, verified each step. Adsorption tests showed a strong pH dependence, working best between pH\u20096 and 7. For isotherm studies, the maximum capacity for S\u2010KR on S\u2010KR\u2010P was 525\u2009mg\/g, whereas R\u2010KR had 252\u2009mg\/g. The non\u2010imprinted polymers (NIPs) worked similarly for both, around 180\u2009mg\/g. The Langmuir model fits better than the Freundlich model, pointing to adsorption on defined binding sites. With a selectivity coefficient of about 12, it shows effective stereoselective recognition, making S\u2010KR\u2010P a great option for separating chiral ketorolac.\n                  <\/jats:p>","DOI":"10.1002\/chir.70135","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:15:31Z","timestamp":1788336931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Post\u2010Crosslinked Hydrazidine\u2010Functionalized Resorcinol\u2013Formaldehyde Imprinted Polymer for Selective S\u2010Ketorolac Recognition"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3227-3965","authenticated-orcid":false,"given":"Rua B.","family":"Alnoman","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Science in Yanbu Taibah University  Yanbu Governorate Saudi 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