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The chirality of\n                    <jats:sc>d<\/jats:sc>\n                    \u2010ribose is essential for ATP's function, ensuring efficient molecular recognition, metabolic stability, and co\u2010evolution with RNA in biological processes. However, origin of chirality of\n                    <jats:sc>d<\/jats:sc>\n                    \u2010ribose is still unknown. Here, we demonstrate that wollastonite, an abundant Earth mineral, catalyzes the formose reaction between formaldehyde and glycolaldehyde and achieves high enantioselectivity (63.3%\u201391.3%\n                    <jats:italic>ee<\/jats:italic>\n                    ) toward\n                    <jats:sc>d<\/jats:sc>\n                    \u2010ribose. The lower energy barrier for the transition state of\n                    <jats:sc>d<\/jats:sc>\n                    \u2010glyceraldehyde compared to that of\n                    <jats:sc>l<\/jats:sc>\n                    \u2010glyceraldehyde, which possesses a similar configuration to glyceraldehyde, results in the enantioselective synthesis of ribose. Experimental and computational studies reveal that the surface chirality of wollastonite, which is characterized by its wavy atomic arrangement, selectively reduces the adsorption energy of the\n                    <jats:sc>d<\/jats:sc>\n                    \u2010glyceraldehyde intermediate compared to its\n                    <jats:sc>l<\/jats:sc>\n                    \u2010enantiomer. This preferential adsorption kinetically promotes the\n                    <jats:sc>d<\/jats:sc>\n                    \u2010glyceraldehyde pathway and steers the reaction toward\n                    <jats:sc>d<\/jats:sc>\n                    \u2010ribose. Our work establishes wollastonite as an intrinsically enantioselective mineral catalyst, provides a mechanistic foundation for prebiotic chiral selection toward\n                    <jats:sc>d<\/jats:sc>\n                    \u2010ribose, and highlights surface design principles for asymmetric synthesis.\n                  <\/jats:p>","DOI":"10.1002\/chir.70139","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:47:48Z","timestamp":1787215668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prebiotic Absolute Asymmetric Synthesis of\n                    <scp>d<\/scp>\n                    \u2010Ribose on Wollastonite"],"prefix":"10.1002","volume":"38","author":[{"given":"Wendi","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Chemical Science and Engineering Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Engineering Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Engineering Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanzheng","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Engineering Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6119-4895","authenticated-orcid":false,"given":"Lu","family":"Han","sequence":"additional","affiliation":[{"name":"School of Chemical Science and Engineering Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanning","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Synergistic Chem\u2010Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5019-1413","authenticated-orcid":false,"given":"Yuxi","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Synergistic Chem\u2010Bio Synthesis, School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University  Shanghai China"},{"name":"College of Smart Energy Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2019.4943"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/418222a"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/319618a0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/418214a"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201000058"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3841"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903400"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202402055"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","DOI":"10.1002\/syst.202500046","article-title":"Prebiotic Investigations and Reaction Network Analysis on the W\u00f6hler\u2010RNA System","volume":"8","author":"Kurrle N. 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