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However, fabricating chiral nanomaterials remains challenging due to difficulties in sustaining chiral configuration stability. In this study, chiral injectable liquid formulations are fabricated via the co\u2010assembly of phenylalanine\u2010derived enantiomers, flavonoids and chitosan, to tackle the drawbacks of existing chiral nanomaterials for wound healing. The weakly acidic chitosan solution effectively resolved the low\u2010solubility defect of flavonoids extracted from\n                    <jats:italic>Scutellaria baicalensis<\/jats:italic>\n                    , and the chiral transfer strategy among these co\u2010assembled components overcomes the problem of chiral lability. The resulting chiral formulations displayed strong antioxidant and antibacterial capacities and significantly accelerated wound closure in the\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    \u2010infected chronic wound model. This research provides valuable insights for the design of herb\u2010functionalized formulations and lays a foundation for the development of advanced chiral nanomaterials with broad applications in nanomedicine.\n                  <\/jats:p>","DOI":"10.1002\/chir.70142","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:14:25Z","timestamp":1787822065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Herb\u2010Based Chiral Nanomaterials: Potential Application in Wound Healing and Nanomedicine"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6463-6281","authenticated-orcid":false,"given":"Meng","family":"Sun","sequence":"first","affiliation":[{"name":"College of Life Science Xinyang Normal University  Xinyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuowei","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Life Science Xinyang Normal University  Xinyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyue","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Life Science Xinyang Normal University  Xinyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Life Science Xinyang Normal University  Xinyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Science Xinyang Normal University  Xinyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1770-8947","authenticated-orcid":false,"given":"Fengli","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6137-5568","authenticated-orcid":false,"given":"Chuanliang","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13020195"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.03.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b15710"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2018.09.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202303812"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104165"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202101808"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.07.023"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.132508"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801013115"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.0c02419"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1cs15203c"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c00204"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201900046"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.04.023"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b03309"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c03855"},{"key":"e_1_2_8_20_1","unstructured":"S.Mohapatra M. 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