{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:41:57Z","timestamp":1792658517145,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chirality"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A novel \u03c0\u2010conjugated chiral system,\n                    <jats:bold>BT<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>2<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>T<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>4<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>\u2013(CH<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>2<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>OH)<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>2<\/jats:bold>\n                    <\/jats:sub>\n                    , derived from the atropisomeric scaffold 2,2\u2032\u2010bis[2\u2010(5,2\u2032\u2010bithienyl)]\u20103,3\u2032\u2010bithianaphthene (\n                    <jats:bold>BT<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>2<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>T<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>4<\/jats:bold>\n                    <\/jats:sub>\n                    ), was synthesized to provide terminal hydroxymethyl groups for further functionalization. Baseline enantioseparation was achieved by high\u2010performance liquid chromatography using the immobilized polysaccharide\u2010derived Chiralpak IB chiral stationary phase under medium\u2010polarity mobile\u2010phase conditions, which ensured adequate analyte solubility while maintaining excellent chiral recognition. The optimized protocol allowed the isolation of the individual enantiomers in high enantiomeric purity (ee\u2009&gt;\u200999%). The absolute configuration of the separated enantiomers was assigned through a direct correlation between on\u2010line CD detection and CD spectra, providing a reliable stereochemical readout. Under specific synthetic conditions, additional minor species were detected; however, their formation was found to depend on reaction and handling parameters, such as the solvent, and can be minimized by conducting both the synthesis and storage in dichloromethane. Overall,\n                    <jats:bold>BT<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>2<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>T<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>4<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>\u2013(CH<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>2<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>OH)<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>2<\/jats:bold>\n                    <\/jats:sub>\n                    represents a chiral \u03c0\u2010conjugated platform that offers potential applications in enantioselective recognition and in the development of chiroptical and sensing materials.\n                  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