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Recently, new treatment options have become available. Still, predictive biomarkers are needed to optimise treatment for this patient group. In this study, we investigated the predictive value of 60 angiogenic factors in patients with metastatic melanoma treated with the anti\u2010vascular endothelial growth factor A antibody bevacizumab. Thirty\u2010five patients were included in a clinical phase II trial and baseline serum samples were analysed by multiplex protein array. High\u2010serum concentration of Activin A was significantly associated with objective response (OR) to treatment (<jats:italic>p<\/jats:italic> = 0.014). Candidate proteins that indicated a borderline association with treatment response were further investigated by immunohistochemistry. Strong expression of Activin A, interleukin\u20101\u03b2, and urokinase\u2010type plasminogen activator receptor in metastases was significantly associated with OR (<jats:italic>p<\/jats:italic> = 0.011, <jats:italic>p<\/jats:italic> = 0.003, and <jats:italic>p<\/jats:italic> = 0.007, respectively), as well as with markers of activated angiogenesis, such as higher number of proliferating vessels and the presence of glomeruloid microvascular proliferations. Our findings indicate that these proteins may be potential predictive markers for treatment with bevacizumab monotherapy.<\/jats:p>","DOI":"10.1002\/cjp2.116","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T04:00:42Z","timestamp":1537243242000},"page":"53-62","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Predictive value of angiogenic proteins in patients with metastatic melanoma treated with bevacizumab monotherapy"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2665-9527","authenticated-orcid":false,"given":"Cornelia","family":"Schuster","sequence":"first","affiliation":[{"name":"Centre for Cancer Biomarkers CCBIO, Department of Clinical Medicine University of Bergen  Bergen Norway"},{"name":"Department of Oncology and Medical Physics Haukeland University Hospital  Bergen 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