{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T16:19:31Z","timestamp":1781540371216,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["154290"],"award-info":[{"award-number":["154290"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology CR"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ovarian carcinoma histotypes are distinct diseases with variable clinical outcomes and response to treatment. There is a need for new subtype\u2010specific treatment modalities, especially for women with widespread and chemo\u2010resistant disease. Stimulator of interferon genes (STING) is a part of the cGAS\u2013STING pathway that mediates innate immune defence against infectious DNA\u2010containing pathogens and also detects tumour\u2010derived DNA and generates intrinsic antitumour immunity. The STING signalling pathway is suppressed by several mechanisms in a variety of malignant diseases and, in some cancers that may be a requirement for cellular transformation. The aim of this study was to use immunohistochemistry to evaluate STING protein expression across normal tissue, paratubal and ovarian cysts, and ovarian tumour histotypes including ovarian carcinomas. Herein, we show that the fallopian tube ciliated cells express STING protein, whereas the secretory cells are negative. STING expression differs among ovarian cancer histotypes; low\u2010grade serous ovarian carcinomas and serous borderline tumours have uniform high STING expression, while high\u2010grade serous and endometrioid carcinomas have heterogeneous expression, and clear cell and mucinous carcinomas show low expression. As low\u2010grade serous carcinomas are known to be genomically stable and typically lack a prominent host immune response, the consistently high STING expression is unexpected. High STING expression may reflect pathway activation or histogenesis and the mechanisms may be different in different ovarian carcinoma histotypes. Further studies are needed to determine whether the STING signalling pathway is active and whether these tumours would be candidates for therapeutic interventions that trigger innate immunity activation.<\/jats:p>","DOI":"10.1002\/cjp2.230","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T10:43:29Z","timestamp":1623926609000},"page":"548-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<scp>STING<\/scp> pathway expression in low\u2010grade serous carcinoma of the ovary: an unexpected therapeutic opportunity?"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2685-0877","authenticated-orcid":false,"given":"Jutta","family":"Huvila","sequence":"first","affiliation":[{"name":"Department of Biomedicine University of Turku  Turku Finland"},{"name":"Department of Molecular Oncology BC Cancer Research Center  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-9351","authenticated-orcid":false,"given":"Dawn R","family":"Cochrane","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology BC Cancer Research Center  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Ta","sequence":"additional","affiliation":[{"name":"Genetic Pathology Evaluation Centre Vancouver General Hospital  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Chow","sequence":"additional","affiliation":[{"name":"Genetic Pathology Evaluation Centre Vancouver General Hospital  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall","family":"Greening","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology BC Cancer Research Center  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony N","family":"Karnezis","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California Davis Medical Center  Sacramento CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8319-6763","authenticated-orcid":false,"given":"Analisa","family":"DiFeo","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Michigan Medical School  Ann Arbor MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4934-3322","authenticated-orcid":false,"given":"David G","family":"Huntsman","sequence":"additional","affiliation":[{"name":"Department of Molecular Oncology BC Cancer Research Center  Vancouver BC Canada"},{"name":"Genetic Pathology Evaluation Centre Vancouver General Hospital  Vancouver BC Canada"},{"name":"Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31937"},{"key":"e_1_2_7_4_1","unstructured":"Key Statistics for Ovarian Cancer [Internet]. 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