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Only a few studies have focused on the genetic relationship between the two advanced carcinomas and coexisting differentiated thyroid carcinomas (DTCs). In the present study, we investigated clinicopathologic features and genetic profiles in 57 ATC and PDTC samples, among which 33 cases had concomitant DTC components or DTC history. We performed immunohistochemistry for BRAF V600E, p53, and PD\u2010L1 expression, Sanger sequencing for <jats:italic>TERT<\/jats:italic> promoter and <jats:italic>RAS<\/jats:italic> mutations, and fluorescence <jats:italic>in situ<\/jats:italic> hybridization for <jats:italic>ALK<\/jats:italic> and <jats:italic>RET<\/jats:italic> rearrangements. We found that ATCs and PDTCs shared similar gene alterations to their coexisting DTCs, and most DTCs were aggressive subtypes harboring frequent <jats:italic>TERT<\/jats:italic> promoter mutations. A significantly higher proportion of ATCs expressed p53 and PD\u2010L1, and a lower proportion expressed PAX\u20108 and TTF\u20101, than the coexisting DTCs. Our findings provide more reliable evidence that ATCs and PDTCs are derived from DTCs.<\/jats:p>","DOI":"10.1002\/cjp2.356","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T22:45:12Z","timestamp":1705617912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Anaplastic and poorly differentiated thyroid carcinomas: genetic evidence of high\u2010grade transformation from differentiated thyroid carcinoma"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3447-6157","authenticated-orcid":false,"given":"Haiyan","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Pathology The Affiliated Hospital of Qingdao University  Qingdao PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingnan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Basic Medicine, Qingdao 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