{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:01:07Z","timestamp":1793790067305,"version":"4.6.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["pathsocjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pathology CR"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cervical cancer is one of the commonest cancers worldwide, especially in developing countries. In early stage disease, a variety of pathological parameters are of prognostic value but currently this does not include tumour grade which, for a number of reasons, is of limited or no value in cervical squamous cell carcinomas. In a recent article in this journal, Jesinghaus and colleagues investigated a novel histopathological grading system based on tumour budding and cell nest size, which has been shown to outperform conventional grading systems for squamous cell carcinoma at several other sites such as lung, oral cavity, and oesophagus in terms of patient prognostication. They tested the prognostic value of this grading system in two independent cohorts of cervical squamous cell carcinoma. The grading system proved to be a highly effective, stage\u2010independent prognosticator in both cohorts with small cell nest size and high tumour budding indicative of a poor prognosis. It is hoped that the results of this study will be validated in additional independent larger cohorts and will act as an impetus for the development of a meaningful and easy\u2010to\u2010implement grading system for cervical squamous cell carcinoma. As comparable tumour budding\/cell nest size\u2010based grading systems have been shown to be of prognostic value for squamous cell carcinomas at other sites, this shows the potential of these parameters to serve as the basis for a common grading system applicable to squamous cell carcinomas of different anatomic sites.<\/jats:p>","DOI":"10.1002\/cjp2.98","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T14:52:50Z","timestamp":1519224770000},"page":"81-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Towards developing a meaningful grading system for cervical squamous cell carcinoma"],"prefix":"10.1002","volume":"4","author":[{"given":"W Glenn","family":"McCluggage","sequence":"first","affiliation":[{"name":"Department of Pathology Belfast Health and Social Care Trust Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000412"},{"key":"e_1_2_8_3_1","article-title":"ESGO\/ESTRO\/ESP guidelines for the management of patients with cervical cancer","author":"Cibula D","journal-title":"Int J Gynecol Cancer"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.95"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13173"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000865"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00937-2015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(90)90072-S"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920401)69:7<1750::AID-CNCR2820690717>3.0.CO;2-S"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198506000-00010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/pgp.0b013e3180341111"},{"key":"e_1_2_8_12_1","first-page":"2829","article-title":"Prospective malignancy grading of invasive squamous carcinoma of the uterine cervix. 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