{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:20:31Z","timestamp":1761708031023},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T00:00:00Z","timestamp":1172448000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The measurement of cardiac troponins (cTn) is of considerable usefulness in the diagnosis of acute coronary syndrome. Abnormal levels of serum cTn are occasionally found in patients who are not suffering a myocardial infarction. This may be observed in several well\u2010known situations including pulmonary embolism, pericarditis, myocarditis, coronary vasospasm, sepsis, congestive heart failure, supraventricular tachycardia with hemodynamic compromise, re\u2010nal insufficiency, and prolonged strenuous endurance exercise. Endogenous antibodies such as heterophile antibodies, rheumatoid factor, and other autoantibodies are known to interfere with the immunoassay measurements of many different analytes, including the widely used Abbot AxSYM\u2122 cTnI analyzer. Other sources of circulating antibodies include immunotherapies, vaccinations, or blood transfusions that may interfere with these immunoassays as well. We examine the case of a 48\u2010year\u2010old man with a history of hypercholesterolemia and obesity who presented with chest pain and was found to have elevated Tn I levels on two separate occasions. Further work\u2010up revealed that the Tn I levels were spuriously elevated because the patient's blood revealed a normal cTnI level when mixed with polyethylene glycol to inactivate any antibodies interfering with the cTnI assay.<\/jats:p>","DOI":"10.1002\/clc.20006","type":"journal-article","created":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T17:14:31Z","timestamp":1172510071000},"page":"92-94","source":"Crossref","is-referenced-by-count":20,"title":["Falsely Elevated Cardiac Troponin I Levels"],"prefix":"10.1002","volume":"30","author":[{"given":"Amgad N.","family":"Makaryus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary N.","family":"Makaryus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Hassid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)01436-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1197\/j.aem.2004.03.022"},{"issue":"12","key":"e_1_2_1_4_2","first-page":"1212","article-title":"Troponin I and T levels in renal failure patients without acute coronary syndrome: A systematic review of the literature","volume":"20","author":"Needham DM","year":"2004","journal-title":"Can J Cardiol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/hj.1999.v137.92413"},{"issue":"7","key":"e_1_2_1_6_2","first-page":"1258","article-title":"Falsely elevated cardiac troponin\u2010I in patients with seropositive rheumatoid arthritis","volume":"32","author":"Kenny PR","year":"2005","journal-title":"J Rheumatol"},{"issue":"5","key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"606","DOI":"10.5858\/2002-126-0606-FPACTI","article-title":"False\u2010positive AxSYM cardiac troponin I results in a 53\u2010year\u2010old woman","volume":"126","author":"Knoblock RJ","year":"2002","journal-title":"Arch Pathol Lab Med"},{"issue":"12","key":"e_1_2_1_8_2","first-page":"2750","article-title":"False positive elevation of cardiac troponin I in seropositive rheumatoid arthritis","volume":"28","author":"Katwa G","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.10.2212"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4037\/ajcc1998.7.6.418","article-title":"Cardiac biomarkers: Past, present, and future","volume":"7","author":"Adams JE","year":"1998","journal-title":"Am J Crit Care"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00200-8"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1062-1458(98)00061-0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.6.1198"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1309\/EHMY-7WU1-UYE7-EE99"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.20006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.20006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T20:04:59Z","timestamp":1700078699000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.20006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1002\/clc.20006"],"URL":"https:\/\/doi.org\/10.1002\/clc.20006","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}