{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:56:58Z","timestamp":1761807418510},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,5,12]],"date-time":"2008-05-12T00:00:00Z","timestamp":1210550400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Significant myocardial scar in the posterolateral left ventricle (LV) has been associated with a diminished response to cardiac resynchronization therapy (CRT) in patients with coronary artery disease, but the effects of resting perfusion abnormalities in nonischemic cardiomyopathy (NICM) are yet to be described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We sought to characterize the effect of myocardial perfusion abnormalities upon echocardiographic outcomes of CRT in patients with NICM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one patients (mean age 64.4 \u00b1 13.3; 71.4% male; mean left ventricular ejection fraction [LVEF] 20.2 \u00b1 6.9%) with NICM who underwent CRT implantation and Thallium\u2010201 single positron emission computed tomography (SPECT) myocardial perfusion imaging (MPI) were included. MPI studies were read quantitatively, assigning each of 17 myocardial segments a perfusion score (0\u20134) and cumulatively generating a summed perfusion score (SPS). The LV lead position was determined by chest radiography. Echocardiograms were performed both before and after (median 12 mo) CRT in 15 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Echocardiographic response, defined as \u2265 15% relative increase in LVEF, was documented in 8 (53.3%) of 15 patients. All patients (5\/5) with an SP \u2a7d6 responded to CRT, whereas only 30.0% (3\/10) with an SPS \u2265 6 responded (odds ratio 3.33 [95% confidence interval {CI} 1.29\u20108.59]; p = 0.01). All nonresponders had inferior perfusion defects. Defect density adjacent to the LV lead tip had little demonstrable effect upon CRT efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of significant myocardial perfusion defects negatively influences echocardiographic response to CRT in NICM. These findings warrant prospective confirmation and histopathological correlation with explanted hearts. Copyright \u00a9 2008 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.20116","type":"journal-article","created":{"date-parts":[[2008,5,12]],"date-time":"2008-05-12T21:16:56Z","timestamp":1210627016000},"page":"217-224","source":"Crossref","is-referenced-by-count":8,"title":["Baseline Scintigraphic Abnormalities by Myocardial Perfusion Imaging Predict Echocardiographic Response to Cardiac Resynchronization Therapy in Nonischemic Cardiomyopathy"],"prefix":"10.1002","volume":"31","author":[{"given":"Evan C.","family":"Adelstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samir","family":"Saba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,5,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013168"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.08.016"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.543678"},{"key":"e_1_2_1_7_2","first-page":"1","article-title":"Postero\u2010lateral scar tissue resulting in nonresponse to cardiac resynchronization therapy","volume":"12","author":"Bleeker GB","year":"2006","journal-title":"J Cardiovasc Electr"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2004.02.001"},{"key":"e_1_2_1_9_2","first-page":"164","article-title":"Myocardial perfusion imaging using gated SPECT in heart failure patients undergoing cardiac resynchronization therapy","volume":"45","author":"Sciagra R","year":"2004","journal-title":"J Nucl Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-3581(03)00456-2"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03012125"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.12.024"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102975"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.1.175"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(89)80014-8"},{"key":"e_1_2_1_16_2","first-page":"707","article-title":"T1\u2010201 single\u2010photon emission computed tomography for clinical assessment of dilated cardiomyopathy","volume":"14","author":"Omori Y","year":"1984","journal-title":"J Cardiogr"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.20116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.20116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T19:01:16Z","timestamp":1699988476000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.20116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1002\/clc.20116"],"URL":"https:\/\/doi.org\/10.1002\/clc.20116","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}