{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,21]],"date-time":"2024-07-21T02:48:52Z","timestamp":1721530132986},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T00:00:00Z","timestamp":1194998400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010density lipoprotein (HDL) could enhance inflammation in atherogenesis when inflammatory response is present, and the activity of paraoxonase and antioxidant in HDL in the elderly is significantly decreased. There might be a different role for high\u2010density lipoprotein cholesterol (HDL\u2010C) between different age groups in patients with coronary heart disease (CHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For this study, 225 inpatients with CHD (coronary atherosclerosis stenosis \u2265 50% on \u2265 1 major coronary arteries by coronary angiography), and 80 without CHD; 120 resting unstable angina patients, and 68 with stable angina were consecutively recruited. Risk factors were analyzed for CHD and resting unstable angina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High\u2010density lipoprotein cholesterol in resting unstable angina was higher than that in stable angina (1.24 \u00b1 1.05 versus 1.05 \u00b1 0.29 mmol\/L, p = 0.032). After adjustment for age, sex, physical inactivity, hypertension, diabetes, C\u2010reactive protein, triglycerides, total cholesterol (TC) and low\u2010density lipoprotein cholesterol (LDL\u2010C) the adjusted odds ratio (OR) (95% CI) of resting unstable angina was 10.19 (2.18\u201347.6, p = 0.003) for HDL\u2010C. Risk factors were further investigated in different age groups. Adjusted OR of CHD associated with HDL\u2010C in &lt; 55\u2010year\u2010old group was 0.09 (0.01\u20130.66, p = 0.018), in \u2265 55\u2010year\u2010old group it was 0.55 (0.08\u20133.82, p &gt; 0.05). Adjusted OR of resting unstable angina associated with high HDL\u2010C was 19.24 (2.86\u2013129.4, p = 0.002) in patients aged \u2265 55 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elevated HDL\u2010C might be an independent risk factor for resting unstable angina, even though HDL\u2010C could play a much more important role in protection against coronary stenosis in younger or middle\u2010aged persons. Copyright \u00a9 2007 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.20137","type":"journal-article","created":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T20:50:33Z","timestamp":1195073433000},"page":"576-580","source":"Crossref","is-referenced-by-count":1,"title":["Is Elevated High\u2010density Lipoprotein Cholesterol Always Good for Coronary Heart Disease?"],"prefix":"10.1002","volume":"30","author":[{"given":"Yuhua","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuejin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinglin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.06.080"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890510007322"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03410050061031"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.12.1585"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.20.1615"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908053410604"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.16.1907"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(00)90238-2"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0320"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2003.08.001"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530070037026"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300520-JLR200"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.06.012"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2005.05.008"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-004-0794-4"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-001-0640-z"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.08.065"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119554"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.085"},{"key":"e_1_2_1_21_2","first-page":"365","article-title":"Transient microvascular vasoconstriction: a possible cause of unstable angina","volume":"1","author":"Niccoli G","year":"2000","journal-title":"Ital Heart J"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.20137","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.20137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T06:58:31Z","timestamp":1700031511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.20137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["10.1002\/clc.20137"],"URL":"https:\/\/doi.org\/10.1002\/clc.20137","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}