{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T21:33:01Z","timestamp":1782163981459,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T00:00:00Z","timestamp":1206489600000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>No data are available on survival analysis and longitudinal evolution of patients with gene mutations of beta\u2010myosin heavy chain (<jats:italic>MYH<\/jats:italic><jats:sup>7<\/jats:sup>) and myosin binding protein C (<jats:italic>MYBPC<\/jats:italic><jats:sup>3<\/jats:sup>) in Chinese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>To prospectively investigate whether different gene mutations confer distinct prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective study in 70 HCM patients and 46 genetically affected family members without HCM\u2010phenotype with direct DNA sequencing of <jats:italic>MYH<\/jats:italic><jats:sup>7<\/jats:sup> and <jats:italic>MYBPC<\/jats:italic><jats:sup>3<\/jats:sup>, clinical assessments, and 5.8 \u00b1 1.8 years follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After follow\u2010up, more surgical intervention (8\/52 versus 0\/18, p &lt; 0.001), higher sudden death risk (7\/52 versus 0\/18, p &lt; 0.001) and shorter life span were found in patients with <jats:italic>MYH<\/jats:italic><jats:sup>7<\/jats:sup> mutations than in patients with <jats:italic>MYBPC<\/jats:italic><jats:sup>3<\/jats:sup> mutations (45.1 \u00b1 14.0 versus 73.5 \u00b1 7.5 years, p    =     0.03). Seven of the 27 mutation carriers of <jats:italic>MYH<\/jats:italic><jats:sup>7<\/jats:sup> had clinical presentations of HCM, but no carriers of <jats:italic>MYBPC<\/jats:italic><jats:sup>3<\/jats:sup> mutations developed to HCM during follow\u2010up. Maximal wall thickness was thicker in the patients carrying mutations in the global region of <jats:italic>MYH<\/jats:italic><jats:sup>7<\/jats:sup> than in those carrying mutations in the rod region of <jats:italic>MYH<\/jats:italic><jats:sup>7<\/jats:sup> (21.5 \u00b1 6.6 versus 15 \u00b1 6.1 mm, p &lt; 0.05) at baseline. More sudden death (7\/41 versus 0\/11) and left ventricular dysfunction (NYHA Class III \u223c IV, 17\/32 versus 1\/10) were identified in patients with mutations in the global region of <jats:italic>MYH<\/jats:italic><jats:sup>7<\/jats:sup> than in patients with other mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>MYH<\/jats:italic><jats:sup>7<\/jats:sup> mutations, especially in the global region, cause malignant clinical phenotypes Copyright \u00a9 2008 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.20151","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T15:27:23Z","timestamp":1206545243000},"page":"114-118","source":"Crossref","is-referenced-by-count":28,"title":["Worse Prognosis with Gene Mutations of Beta\u2010myosin Heavy Chain than Myosin\u2010Binding Protein C in Chinese Patients with Hypertrophic Cardiomyopathy"],"prefix":"10.1002","volume":"31","author":[{"given":"Rutai","family":"Hui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tujun","family":"Huan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,3,26]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00242-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.10.1308"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204233261703"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804303381802"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.07.045"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.09.016"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.05.009"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.10.1179"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021332"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.1.214"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi204"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01900-9"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2005.02.008"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.1.22"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.20151","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.20151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T20:47:47Z","timestamp":1699994867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.20151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["10.1002\/clc.20151"],"URL":"https:\/\/doi.org\/10.1002\/clc.20151","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}