{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T22:44:51Z","timestamp":1759099491160},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T00:00:00Z","timestamp":1197244800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Atrial fibrillation is the most common cardiac arrhythmia and a major risk factor for cerebrovascular accident, including ischemic stroke and transient ischemic attack.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Ischemic cerebrovascular accident is associated with increasing age and cardiovascular and cerebrovascular disease in primary care patients with atrial fibrillation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the U.K. General Practice Research Database, we identified patients with chronic atrial fibrillation who were alive 1 month after initial diagnosis (n = 906). Potential cases of cerebrovascular accident were identified and confirmed by the primary care physician. The incidence of cerebrovascular accident was calculated. A nested case\u2010control analysis was performed to identify factors associated with cerebrovascular accident among patients with chronic atrial fibrillation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a mean follow\u2010up period of 1.8 years (range: 0\u20133.9 years), 60 patients with atrial fibrillation were diagnosed with a new cerebrovascular accident (22 cases with transient ischemic attack and 38 with ischemic stroke). The incidence of new cerebrovascular accident was 3.6 per 100 patient\u2010years (95% confidence interval [CI]: 2.8\u20134.6). Increased age (odds ratios [OR] compared with age 40\u201369 years: 3.5 [95% CI: 1.2\u201310.5] for age 70\u201379 years and 4.9 [95% CI: 1.6\u201315.0] for age &gt; years), prior cerebrovascular event (OR: 3.4; 95% CI: 1.9\u20136.1) and diabetes (OR: 2.2; 95% CI: 1.0\u20134.9) were identified as risk factors for a new cerebrovascular accident.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among patients with atrial fibrillation, risk factors for a new ischemic cerebrovascular accident include previous ischemic stroke or transient ischemic attack, comorbid diabetes, and increasing age. 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