{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:06:02Z","timestamp":1791173162485,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,7,29]],"date-time":"2008-07-29T00:00:00Z","timestamp":1217289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an important cause of sudden death in young adults. On the basis of histopathological findings its pathogenesis may involve both a genetic origin and an inflammatory process. <jats:italic>Bartonella henselae<\/jats:italic> may cause endomyocarditis and was detected in myocardium from a young male who succumbed to sudden cardiac death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesized that chronic infection with <jats:italic>Bartonella henselae<\/jats:italic> could contribute to the pathogenesis of ARVC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated sera from 49 patients with ARVC for IgG antibodies to <jats:italic>Bartonella henselae.<\/jats:italic> In this study, 58 Swiss blood donors tested by the same method served as controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six patients with ARVC (12%) had positive (&gt;1:256) IgG titres in the immunofluorescence test with <jats:italic>Bartonella henselae.<\/jats:italic> In contrast, only 1 elevated titre was found in 58 controls (p \u2264 0.05). Interestingly, all patients with increased titres had no familial occurrence of ARVC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Further studies in larger patient cohorts seem justified to investigate a possible causal link between chronic <jats:italic>Bartonella henselae<\/jats:italic> and ARVC, in particular its sporadic (nonfamilial) form. Copyright \u00a9 2008 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.20269","type":"journal-article","created":{"date-parts":[[2008,7,29]],"date-time":"2008-07-29T16:03:18Z","timestamp":1217347398000},"page":"469-471","source":"Crossref","is-referenced-by-count":6,"title":["Serological Evidence for the Association of <i>Bartonella henselae<\/i> Infection with Arrhythmogenic Right Ventricular Cardiomyopathy"],"prefix":"10.1002","volume":"31","author":[{"given":"Andreas","family":"H. Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"van der Loo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertrud","family":"M. 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