{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:03:31Z","timestamp":1793232211030,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T00:00:00Z","timestamp":1231804800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sex hormones play an important role in the development of cardiovascular disease. Testosterone and estradiol have been reported to be down\u2010regulated in subjects with coronary artery disease and heart failure, but has not been studied in atrial fibrillation (AF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Levels of sex hormones may be associated with susceptibility to lone AF in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010eight male subjects who had electrocardiographic evidence of paroxysmal or chronic AF and a structurally normal heart on echocardiography were enrolled. Subjects were excluded if they had been taking angiotensin\u2010converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), or statins within 3 mo or had a history of coronary artery disease, rheumatic heart disease, cardiomyopathy, significant valvular disease, hyperthyroidism, or hypertension. Fifty\u2010eight controls were recruited from a healthy outpatient population. Serum total testosterone and estradiol levels were determined using a commercially available radioimmunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean levels of testosterone were significantly lower in subjects with lone AF when compared with controls (476 ng\/dl versus 514 ng\/dl, p = 0.005). No significant differences were found in the estradiol levels between the 2 groups (31.9 pg\/ml versus 32.4 pg\/ml, p = 0.789).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Reduced testosterone levels may be associated with susceptibility to lone AF in men. Copyright \u00a9 2009 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.20423","type":"journal-article","created":{"date-parts":[[2009,1,13]],"date-time":"2009-01-13T20:18:26Z","timestamp":1231877906000},"page":"43-46","source":"Crossref","is-referenced-by-count":40,"title":["Reduced testosterone levels in males with lone atrial fibrillation"],"prefix":"10.1002","volume":"32","author":[{"given":"Lai","family":"Jiangtao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou,","family":"Dongchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia,","family":"Shudong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shang,","family":"Yunpeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Want,","family":"Lihong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng,","family":"Liangrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu,","family":"Jianhua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01107-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.4.1180"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.09.015"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.08.050"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0005"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.526"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1873"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/90.12.787"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.2165\/00129784-200505030-00001"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.058057"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-12-200012190-00010"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/93.10.689"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(93)90245-X"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00515-5"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.07.010"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80042-6"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00092-7"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2001.00737.x"},{"key":"e_1_2_1_20_2","first-page":"385","article-title":"Ventricular endomyocardial biopsy in \u201cprimary\u201d atrial fibrillation","volume":"31","author":"Frustaci A","year":"1986","journal-title":"Cardiologia"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.09.045"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.20423","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.20423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T11:10:09Z","timestamp":1699960209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.20423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1002\/clc.20423"],"URL":"https:\/\/doi.org\/10.1002\/clc.20423","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}