{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:52:48Z","timestamp":1762505568860},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2009,12,14]],"date-time":"2009-12-14T00:00:00Z","timestamp":1260748800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brain natriuretic peptide (BNP) is increasingly being used for screening and monitoring of congestive heart failure. However, the role of BNP in patients with atrial fibrillation (AF) and normal left ventricular function has not been determined. This study investigates serum N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP) level and its clinical implications in patients with AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum NT\u2010proBNP levels were measured by enzyme\u2010linked immunosorbent assay (ELISA) and transthoracic echocardiography was performed in 136 subjects (90 cases with AF and 46 cases with sinus rhythm [SR]). Subjects were excluded if they had a history of myocardial infarction, cardiomyopathy, rheumatic heart disease, or hyperthyroidism that preceded the onset of AF. Controls (n = 30) were from a healthy outpatient primary care population. Potential determinants of serum NT\u2010proBNP levels were identified by univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with AF had higher serum NT\u2010proBNP levels (689.56 \u00b1 251.87 fmol\/ml) than those with SR (456.11 \u00b1 148.14 fmol\/ml, <jats:italic>P<\/jats:italic> &lt; 0.01) and control subjects (415.83 \u00b1 62.02 fmol\/ml, <jats:italic>P<\/jats:italic> &lt; 0.01). Individuals with SR and control subjects did not show significant difference at serum NT\u2010proBNP levels (<jats:italic>P<\/jats:italic> &gt; 0.05). The regression model of serum NT\u2010proBNP levels and clinical predictors showed that presence of AF, older age, and larger right atrial diameter were independently predictive of higher serum NT\u2010proBNP values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with AF were associated with increased serum NT\u2010proBNP levels. Examining the change of serum NT\u2010proBNP levels is helpful to evaluate the cardiac function in patients with AF. 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