{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:00:09Z","timestamp":1791644409260,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,12,30]],"date-time":"2009-12-30T00:00:00Z","timestamp":1262131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated levels of uric acid in serum (SUA) or plasma (PUA) are increasingly related to cardiovascular disease. It is unclear whether they are independent risk factors or simply markers, reflecting association with other traditional risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively assessed results of a lipid profile, including total cholesterol, low\u2010density lipoprotein cholesterol (LDL\u2010C), high\u2010density lipoprotein cholesterol (HDL\u2010C), triglycerides, total cholesterol to HDL\u2010C ratio (TC\/HDL\u2010C), the atherogenic index of plasma (AIP), and lipoprotein(a) (Lp[a]), in a large cohort of unselected adult outpatients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hyperuricemic men displayed significantly increased values of triglycerides and AIP when compared with men with normal PUA levels. In hyperuricemic women, significant differences were observed for HDL\u2010C, triglycerides, TC\/HDL\u2010C, and AIP compared with women with normal PUA levels. The percentage of patients with unfavorable values was statistically higher for triglycerides and AIP in hyperuricemic men; for HDL\u2010C, triglycerides, TC\/HDL\u2010C, and AIP in hyperuricemic women. In multivariable linear regression analysis triglycerides, AIP, and TC\/HDL\u2010C were independently associated with PUA in women, whereas no significant association was observed in men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PUA measurement might be advisable in patients to identify those at increased risk of cardiovascular disease (CVD) who might benefit from further triage and intervention. Copyright \u00a9 2010 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.20511","type":"journal-article","created":{"date-parts":[[2009,12,30]],"date-time":"2009-12-30T22:22:53Z","timestamp":1262211773000},"source":"Crossref","is-referenced-by-count":62,"title":["Epidemiological Association between Uric Acid Concentration in Plasma, Lipoprotein(a), and the Traditional Lipid Profile"],"prefix":"10.1002","volume":"33","author":[{"given":"Giuseppe","family":"Lippi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Montagnana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian","family":"Luca Salvagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Targher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian","family":"Cesare Guidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,23]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01951919"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/clinchem\/35.1.151","article-title":"Differences between values for plasma and serum in tests performed in the Ektachem 700 XR Analyzer, and evaluation of \u201cplasma separator tubes (PST).\u201d","volume":"35","author":"Doumas BT","year":"1989","journal-title":"Clin Chem"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1093\/clinchem\/35.7.1562","article-title":"Serum and plasma compared for use in 19 common chemical tests performed in the Hitachi 737 analyzer","volume":"35","author":"Ciuti R","year":"1989","journal-title":"Clin Chem"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007040426"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.18.2404"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006080865"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2007.095190"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-34-6-1421"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1959.03010160025007"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90209-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02155-5"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000084085"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.69.928"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000150785.39055.e8"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114807"},{"key":"e_1_2_1_17_2","article-title":"The paradoxical relationship between serum uric acid and cardiovascular disease","author":"Lippi G","journal-title":"Clin Chim Acta"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.033175"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.13.1481"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/33.8.731"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.4.308"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.33.4.298"},{"key":"e_1_2_1_25_2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/clinchem\/25.3.371","article-title":"Secondary hypertriglyceridemia and hyperlipoproteinemia in patients with primary symptomatic gout","volume":"25","author":"Naito HK","year":"1979","journal-title":"Clin Chem"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.38.1.31"},{"key":"e_1_2_1_27_2","first-page":"469","article-title":"The elevated prevalence of apolipoprotein E2 in patients with gout is associated with reduced renal excretion of urates","volume":"42","author":"Cardona F","year":"2003","journal-title":"Rheumatology"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(85)90025-3"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.1.25"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(97)00204-4"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1380063"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2006.02.014"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007654507054"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1726-4901(09)70320-X"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.132.3.401"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02283105"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.4.1188"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.2.90"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1080\/713609328"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02785.x"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.20511","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.20511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T14:36:38Z","timestamp":1700577398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.20511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["10.1002\/clc.20511"],"URL":"https:\/\/doi.org\/10.1002\/clc.20511","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}