{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T01:43:38Z","timestamp":1772329418272,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T00:00:00Z","timestamp":1247702400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2009,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Overt thyroid dysfunction, hypothyroidism in particular, may lead to coronary artery disease (CAD). Whether more subtle anomalies of thyroid hormone metabolism influence the progression of CAD remains a matter of speculation.<\/jats:p><\/jats:sec>Hypothesis<\/jats:title>The occurrence of CAD and long\u2010term prognosis in patients without a history of either primary thyroid disease, myocardial infarction, or chronic heart failure is related to serum levels of biologically active free triiodothyronine (fT3).<\/jats:p><\/jats:sec>Methods<\/jats:title>The cohort consisted of 1047 clinically and biochemically euthyroid patients (median age 65.6 y and 69% male) who underwent coronary angiography in our institute for suspected CAD.<\/jats:p><\/jats:sec>Results<\/jats:title>Lower fT3 levels were predictive of both single\u2010vessel (p<\/jats:italic> = 0.012) and multivessel (p<\/jats:italic> = 0.009) CAD. Through a multivariate logistic regression analysis, fT3 was still linked to the presence of CAD (hazard ratio [HR]: 0.48, 95% confidence interval [CI]: 0.34\u20130.68, p < 0.001). After a mean follow\u2010up of 31 months, the survival rate was 95% and total mortality (log\u2010rank 6.75, p<\/jats:italic> = 0.009), as well as cardiac mortality (log\u2010rank 8.26, p<\/jats:italic> = 0.004), was greater among patients with low T3 (fT3 < 2.10 pg\/mL) syndrome. At subsequent multivariate Cox regression analysis, the association between low T3 syndrome and survival was maintained (total mortality HR: 1.80, 95% CI: 1.05\u20133.10, p<\/jats:italic> = 0.034; cardiac mortality HR: 2.58, 95% CI: 1.13\u20135.93, p<\/jats:italic> = 0.025).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In this selected population, fT3 levels were inversely correlated to the presence of CAD and low T3 syndrome conferred an adverse prognosis, even after adjusting for traditional coronary risk factors. 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