{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:33:26Z","timestamp":1783953206818,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T00:00:00Z","timestamp":1259020800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This article aims to investigate the changes of plasma cystatin C concentration (PcyC), and to evaluate the relationship between PcyC and acute coronary syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 126 consecutive patients with coronary artery disease (CAD) were enrolled in this study, consisting of 34 patients with stable angina pectoris (SAP), 56 patients with unstable angina pectoris (UAP), 36 patients with acute myocardial infarction (AMI), and 34 healthy subjects as controls. Plasma cystatin C, high sensitivity C\u2010reactive protein (hs\u2010CRP), total cholesterol (TC), low\u2010density lipoprotein cholesterol (LDL\u2010C), high\u2010density lipoprotein cholesterol (HDL\u2010C), triglycerides (TG), and uric acid (UA) in all subjects were determined. All patients were followed up for 6 months and adverse cardiovascular events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma cystatin C was elevated in CAD. Cystatin C levels were significantly higher in UAP patients than those in SAP patients and controls (2013.83 \u00b1 633.85 ng\/mL vs 1348.41 \u00b1 369.62 ng\/mL and 1509.99 \u00b1 408.65 ng\/mL, <jats:italic>P<\/jats:italic> &lt; 0.05), but were much lower than those in AMI patients (2013.83 \u00b1 633.85 ng\/mL vs 2873.55 \u00b1 1149.48 ng\/mL, <jats:italic>P<\/jats:italic> &lt; 0.05). Patients with AMI also exhibited significantly higher cystatin C levels than SAP patients and the control group (2873.55 \u00b1 1149.48 ng\/mL vs 1348.41 \u00b1 369.62 ng\/mL and 1509.99 \u00b1 408.65 ng\/mL, <jats:italic>P<\/jats:italic> &lt; 0.01). Much higher hs\u2010CRP concentrations were found in UAP patients (1.58 \u00b1 2.81 mg\/L, <jats:italic>P<\/jats:italic> &lt; 0.05) and AMI patients (20.68 \u00b1 18.98 mg\/L, <jats:italic>P<\/jats:italic> &lt; 0.01). Cystatin C was positively and significantly correlated with age, hs\u2010CRP, white blood cells (WBC), creatinine, and UA (<jats:italic>r<\/jats:italic> &gt; 0, <jats:italic>P<\/jats:italic> &lt; 0.05), whereas a significantly negative correlation was observed with HDL\u2010C (<jats:italic>r<\/jats:italic> = \u2212 0.227, <jats:italic>P<\/jats:italic> &lt; 0.05). These coefficients were clearly high for creatinine (<jats:italic>r<\/jats:italic> = + 0.612) and WBC (<jats:italic>r<\/jats:italic> = + 0.459). During the 6 month follow\u2010up, 26 patients were found with adverse cardiovascular events and had significantly higher cystatin C levels than the 22 control patients at admission (2356.73 \u00b1 897.64 ng\/mL vs 1469.51 \u00b1 574.83 ng\/mL, <jats:italic>P<\/jats:italic> &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cystatin C plays an important role in the development of CAD and PcyC is a strong predictor for risk of cardiovascular events. Copyright \u00a9 2009 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.20672","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T21:14:46Z","timestamp":1259097286000},"page":"644-648","source":"Crossref","is-referenced-by-count":30,"title":["Clinical Prognostic Significance of Plasma Cystatin C Levels among Patients With Acute Coronary Syndrome"],"prefix":"10.1002","volume":"32","author":[{"given":"Changjiang","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqing","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,11,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-007-1008-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.054"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e328087bd98"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.09.022"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2680287"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000064453"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2008.05.071"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-007-0989-6"},{"key":"e_1_2_1_10_2","first-page":"269","article-title":"The relationship of cystatin C and cardiovascular diseases","volume":"34","author":"Chen ZK","year":"2003","journal-title":"Sheng Li Ke Xue Jin Zhan"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.10.267"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.053"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/41.12.8245434"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5688(08)70895-X"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.20672","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.20672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T21:15:33Z","timestamp":1699996533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.20672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":13,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["10.1002\/clc.20672"],"URL":"https:\/\/doi.org\/10.1002\/clc.20672","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}