{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:15:09Z","timestamp":1761765309284},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T00:00:00Z","timestamp":1276560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to investigate changes in coagulation activation and platelet activation after transcatheter closure of atrial septal defect (ASD) by determining the levels of specific markers over time to provide insight into preventing postprocedural embolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>We hypothesis that the activation status of coagulation and the platelet would be changed after the closure of ASD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty consecutive patients who underwent transcatheter closure of ASD with the Lifetech ASD occluder (Lifetech Scientific, Shenzhen, China) were included in this prospective study. The serum level of prothrombin fragment 1 + 2 (F1 + 2) and expressions of P\u2010selectin (CD62P) and platelet glycoprotein IIb\/IIIa receptor (CD41a) on the surface of platelets were evaluated at baseline and at 1 day, 1 month, and 3 months after the closure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median F1 + 2 level was 0.96 nmol\/L. This increased to a maximal value of 1.43 nmol\/L at 1 day after closure, but gradually returned to the baseline level at 1 month after closure and remained there at 3 months after closure (medians were 0.98 nmol\/L and 1.08 nmol\/L, respectively). Platelet surface expression of CD62P and CD41a decreased at 1 day, 1 month, and 3 months after closure. For CD62P, average expressions were 8.21% \u00b1  2.11%, 6.28% \u00b1  1.72%, 5.29% \u00b1  1.52%, and 4.41% \u00b1  1.11%, respectively, for baseline and 1 day, 1 month, and 3 months after closure. For CD41a, average expressions were 79.37% \u00b1  14.14%, 71.98% \u00b1  13.77, 56.69% \u00b1  13.05%, and 54.88% \u00b1  11.62%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transcatheter closure of ASD with the Lifetech ASD occluder was associated with significantly increased coagulation activation and decreased platelet activation. No evidence supporting the use of aspirin to prevent thrombus formation after closure was found. Copyright \u00a9 2008 Wiley Periodicals, Inc.<\/jats:p><jats:p>This work was supported by Guangxi Key Technologies R&amp;D Programme, 0472002\u201030, China. The authors have no other funding, financial relationships, or conflicts of interest to disclose.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.20752","type":"journal-article","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T16:32:18Z","timestamp":1276619538000},"source":"Crossref","is-referenced-by-count":9,"title":["Enhanced Prothrombin Formation and Platelet Activation in Chinese Patients After Transcatheter Closure of Atrial Septal Defect"],"prefix":"10.1002","volume":"33","author":[{"suffix":"MD","given":"Xiao\u2010Chun","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD, PhD","given":"Wei\u2010Feng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Kai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Sheng\u2010Lan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Tang\u2010Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0803.2007.00107.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.05.067"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.002"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1182\/blood.V59.5.1086.1086","article-title":"Studies of the prothrombin activation pathway utilizing radioimmunoassays for the F2\/F1 + 2 fragment and thrombin\u2010\u2010antithrombin complex","volume":"59","author":"Teitel JM","year":"1982","journal-title":"Blood"},{"key":"e_1_2_6_6_2","volume-title":"Leukocyte Typing IV: White Cell Differentiation Antigens","author":"Knapp W","year":"1989"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hym157"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.1.329"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.03.022"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000251712.55322.69"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.5.1091"},{"key":"e_1_2_6_12_2","first-page":"393","article-title":"Percutaneous closure of secundum atrial septal defect in adults a single center experience with the amplatzer septal occluder","volume":"15","author":"Staniloae CS","year":"2003","journal-title":"J Invasive Cardiol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0b013e318155741d"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000020009.30736.3F"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0870575"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.20752","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.20752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T15:43:45Z","timestamp":1700581425000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.20752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["10.1002\/clc.20752"],"URL":"https:\/\/doi.org\/10.1002\/clc.20752","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}