{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:37:24Z","timestamp":1768012644175,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T00:00:00Z","timestamp":1276560000000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with heart failure, few data describe the neurohormonal response to nesiritide and furosemide either alone or in combination. This study systematically compared the effects of nesiritide, furosemide, and their combination on natriuresis\/diuresis and plasma aldosterone in patients with chronic stable heart failure who were relatively diuretic resistant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Natriuretic, diuretic, and neurohormonal responses to furosemide and nesiritide will differ when these agents are administered alone vs. in combination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight subjects completed a multicenter, open\u2010label, three\u2010arm crossover study. Each subject received the following treatments in random order on alternate days: (1) furosemide, 40 mg intravenous bolus; (2) nesiritide, 2 \u00b5g\/kg intravenous bolus followed by a 0.01 \u00b5g\/kg\/min infusion for 6 hours; (3) both furosemide and nesiritide, with furosemide given at least 15 minutes after initiation of nesiritide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma aldosterone increased by 2.2 \u00b1 1.6 ng\/dL after furosemide alone, decreased by 3.9 \u00b1 1.6 ng\/dL after nesiritide alone (<jats:italic>P<\/jats:italic> = 0.005 vs furosemide alone and <jats:italic>P<\/jats:italic> = 0.56 vs furosemide plus nesiritide), and decreased by 2.8 \u00b1 1.6 ng\/dL after furosemide plus nesiritide (<jats:italic>P<\/jats:italic> = 0.02 vs furosemide alone).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Furosemide alone produced natriuresis\/diuresis and a prompt rise in plasma aldosterone values. Nesiritide alone produced no significant natriuresis\/diuresis, but decreased plasma aldosterone values. When furosemide was administered on a background of nesiritide infusion, the observed natriuresis\/diuresis was similar to that seen with furosemide alone, without the anticipated increase in plasma aldosterone observed with furosemide alone. Copyright \u00a9 2010 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/clc.20787","type":"journal-article","created":{"date-parts":[[2010,6,16]],"date-time":"2010-06-16T09:04:58Z","timestamp":1276679098000},"page":"330-336","source":"Crossref","is-referenced-by-count":16,"title":["Natriuretic and Neurohormonal Responses to Nesiritide, Furosemide, and Combined Nesiritide and Furosemide in Patients With Stable Systolic Dysfunction"],"prefix":"10.1002","volume":"33","author":[{"given":"Domenic","family":"Sica","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron M.","family":"Oren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mildred D.","family":"Gottwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger M.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Scios 351 Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,15]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"197","article-title":"Diuretic therapy in congestive heart failure","volume":"6","author":"Brater DC.","year":"2000","journal-title":"Congest Heart Fail"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00365-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000047397"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc1102.105264"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-5299.2002.0758.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.16.1963"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D481"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.1.91"},{"key":"e_1_2_1_10_2","first-page":"F63","article-title":"Effect of BNP on renal hemodynamics, tubular function and vasoactive hormones in humans","volume":"274","author":"Jensen KT","year":"1998","journal-title":"Am J Physiol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.84.4.1581"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-5299.2007.06022.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40678-0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199630030-00004"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0590443"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-1-1"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.57.1.17"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.5.1724"}],"container-title":["Clinical Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fclc.20787","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/clc.20787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T14:52:03Z","timestamp":1700578323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/clc.20787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1002\/clc.20787"],"URL":"https:\/\/doi.org\/10.1002\/clc.20787","archive":["Portico"],"relation":{},"ISSN":["0160-9289","1932-8737"],"issn-type":[{"value":"0160-9289","type":"print"},{"value":"1932-8737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}