{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:53:39Z","timestamp":1788998019075,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Cardiology"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital coronary abnormality associated with early infant mortality and adult sudden death. As it predominantly presents in the first year of life, diagnosis in living adults is extremely rare. Current management is based on limited case series or extrapolated from pediatric cases. Modern advances in noninvasive cardiac imaging have substantially increased the number of diagnoses, uncovering a large adult population that has not been reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis:<\/jats:title>\n                    <jats:p>The availability of newer diagnostic modalities correlates with an increasing incidence in an older cohort, and true association between sudden death and ALCAPA may be lower, especially among older patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A comprehensive literature search was performed for all case reports of ALCAPA on MEDLINE and PubMed using the keywords ALCAPA, Bland\u2010White\u2010Garland, and coronary anomaly; and augmented by references from published case reports from 1908 to 2008. All adult cases, defined by age 18 years and older, were reviewed for this article.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>One hundred fifty\u2010one adult cases of ALCAPA are described, in addition to the case of an asymptomatic 53\u2010year\u2010old woman. The average reported age was 41 years old with the oldest being 83. Sixty\u2010six percent of the patients presented with symptoms of angina, dyspnea, palpitations, or fatigue; 17% presented with ventricular arrhythmia, syncope, or sudden death; and 14% were asymptomatic. Twelve percent were diagnosed at autopsy. The majority had some form of surgical correction during their clinical course.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>ALCAPA is a rare and life\u2010threatening condition in adults. The availability of newer, less invasive diagnostic modalities has resulted in more frequent identification of this condition in an older cohort. \u00a9 2011 Wiley Periodicals, Inc.<\/jats:p>\n                    <jats:p>The authors have no funding, financial relationships, or conflicts of interest to disclose.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/clc.20848","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T18:37:16Z","timestamp":1301683036000},"page":"204-210","source":"Crossref","is-referenced-by-count":214,"title":["Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery in Adults: A Comprehensive Review of 151 Adult Cases and A New Diagnosis in a 53\u2010Year\u2010Old Woman"],"prefix":"10.1002","volume":"34","author":[{"given":"James M.","family":"Yau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan J.","family":"Halpern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Fischman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.21.2.149"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810210110"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.057299"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90277-5"},{"key":"e_1_2_6_6_2","first-page":"657","article-title":"Ein seltener Fall von Herzmissbildung","volume":"31","author":"Konstantinowitsch W.","year":"1906","journal-title":"Prager med Wchnschr."},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01994667"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.38.2.403"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(57)90130-8"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90207-7"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.1995.tb00617.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2006.00406.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1067\/mje.2002.115658"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00913-5"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.185.2.01850326"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.62.219"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.292085059"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03633-0"},{"key":"e_1_2_6_19_2","first-page":"225","article-title":"Cber den Ursprung einer akzessorischen A. coronaria aus der A. pulmonalis.","volume":"24","author":"Krause W.","year":"1865","journal-title":"Ztschr rat Med."},{"key":"e_1_2_6_20_2","first-page":"26","article-title":"Two cases of an abnormal coronary artery of the heart arising from the pulmonary artery: with some remarks upon the effect of this anomaly in producing cirsoid dilatation of the vessels","volume":"20","author":"Brooks SJ.","year":"1886","journal-title":"J Anat Physiol."},{"key":"e_1_2_6_21_2","first-page":"420","volume-title":"Modern Medicine: Its Theory and Practice","author":"Abbott ME.","year":"1908"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(33)90140-4"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(47)90005-7"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.17.6.1001"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.17.6.1062"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.22.4.591"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.29.2.167"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(60)90518-4"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.29.2.163"},{"key":"e_1_2_6_30_2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0022-5223(19)34868-8","article-title":"Anomalous origin of the left coronary artery. 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